Entity Details

Primary name PRKRA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75569
EntryNamePRKRA_HUMAN
FullNameInterferon-inducible double-stranded RNA-dependent protein kinase activator A
TaxID9606
Evidenceevidence at protein level
Length313
SequenceStatuscomplete
DateCreated2006-02-21
DateModified2021-06-02

Ontological Relatives

GenesPRKRA

GO terms

Show/Hide Table
GOName
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0008047 enzyme activator activity
GO:0008285 negative regulation of cell population proliferation
GO:0009615 response to virus
GO:0010586 miRNA metabolic process
GO:0016020 membrane
GO:0016032 viral process
GO:0019899 enzyme binding
GO:0030422 production of siRNA involved in RNA interference
GO:0031054 pre-miRNA processing
GO:0034599 cellular response to oxidative stress
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0042473 outer ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0048705 skeletal system morphogenesis
GO:0050821 protein stabilization
GO:0070578 RISC-loading complex
GO:0070883 pre-miRNA binding
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR032478 Staufen, C-terminalDomainDomain
IPR033363 Interferon-inducible double-stranded RNA-dependent protein kinase activator AFamilyFamily
IPR044465 PRKRA, first double-stranded RNA binding domainDomainDomain
IPR044466 PRKRA, second double-stranded RNA binding domainDomainDomain
IPR044467 PRKRA, third double-stranded RNA binding domainDomainDomain

Diseases

Show/Hide Table

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
PRKRA_HUMANCSN6_HUMANBioGRID, HPRD, IntAct16169070 details
PRKRA_HUMANGDF9_HUMANBioGRID, HPRD, IntAct16169070 details
PRKRA_HUMANPRKRA_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 22214662 25416956 32296183 details
PRKRA_HUMANSETB1_HUMANBioGRID, HPRD, IntAct16169070 details
PRKRA_HUMANDICER_HUMANbhf-ucl, BioGRID, HPRD, IntAct, MINT16424907 21858095 23661684 24778252 details
PRKRA_HUMANTRBP2_HUMANBioGRID, HPRD, IntAct, MINT16424907 21900206 24778252 25416956 25910212 32296183 details
PRKRA_HUMANLYAR_HUMANBioGRID, IntAct, MINT21516116 25416956 31515488 details
PRKRA_HUMANRPB7_HUMANBioGRID, IntAct21988832 details
PRKRA_HUMANCEBPZ_HUMANBioGRID, MINT21900206 details
PRKRA_HUMANCE126_HUMANBioGRID, MINT21900206 details
PRKRA_HUMANNKRF_HUMANBioGRID, IntAct, MINT21900206 32296183 details
PRKRA_HUMANSHC1_HUMANBioGRID, MINT21900206 details
PRKRA_HUMANSNX5_HUMANBioGRID, MINT21900206 details
PRKRA_HUMANZFP28_HUMANBioGRID, MINT21900206 details
PRKRA_HUMANZN746_HUMANBioGRID, MINT21900206 details
PRKRA_HUMANRABEK_HUMANBioGRID, MINT21900206 details
PRKRA_HUMANE2AK2_HUMANBioGRID, DIP, HPRD, IntAct11238927 11985496 16785445 21903422 23455922 24778252 32296183 9687506 details
PRKRA_HUMANZMAT3_HUMANBioGRID, IntAct25416956 details
PRKRA_HUMANSTAU1_HUMANBioGRID, IntAct23125841 28514442 29395067 32296183 details
PRKRA_HUMANECHP_HUMANBioGRID, IntAct32296183 details
PRKRA_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
PRKRA_HUMANSTRBP_HUMANBioGRID, IntAct28514442 32296183 details
PRKRA_HUMANPIAS2_HUMANBioGRID, IntAct32296183 details
PRKRA_HUMANRED1_HUMANBioGRID, IntAct32296183 details
PRKRA_HUMANZMAT4_HUMANBioGRID, IntAct32296183 details
PRKRA_HUMANCDC42_HUMANIntAct21311754 details
PRKRA_HUMANUBC9_HUMANBioGRID22214662 details
PRKRA_HUMANAGO2_HUMANbhf-ucl, HPRD, MINT16424907 23661684 details
PRKRA_HUMANDDX58_HUMANBioGRID, DIP, UniProt23870315 28591694 details
PRKRA_HUMANRBM34_HUMANBioGRID, IntAct24778252 28514442 details
PRKRA_HUMANIFIH1_HUMANBioGRID, DIP28591694 details
PRKRA_HUMANCC124_HUMANBioGRID24778252 details
PRKRA_HUMANDDX50_HUMANBioGRID24778252 details
PRKRA_HUMANFBW1A_HUMANBioGRID28049764 details
PRKRA_HUMANSUH_HUMANBioGRID30967258 details
PRKRA_HUMANRB_HUMANHPRD9010216 details
PRKRA_HUMANP53_HUMANHPRD9010216 details
PRKRA_HUMANTIRAP_HUMANHPRD11526399 details