Entity Details

Primary name OTC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00480
EntryNameOTC_HUMAN
FullNameOrnithine transcarbamylase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length354
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesOTC

GO terms

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GOName
GO:0000050 urea cycle
GO:0001889 liver development
GO:0004585 ornithine carbamoyltransferase activity
GO:0005543 phospholipid binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006593 ornithine catabolic process
GO:0007494 midgut development
GO:0010043 response to zinc ion
GO:0016597 amino acid binding
GO:0019240 citrulline biosynthetic process
GO:0032868 response to insulin
GO:0042301 phosphate ion binding
GO:0042450 arginine biosynthetic process via ornithine
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0055081 anion homeostasis
GO:0070781 response to biotin
GO:0097272 ammonium homeostasis

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR002292 Ornithine/putrescine carbamoyltransferaseFamilyFamily
IPR006130 Aspartate/ornithine carbamoyltransferaseFamilyFamily
IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domainDomainDomain
IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P bindingDomainDomain
IPR036901 Aspartate/ornithine carbamoyltransferase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00129 OrnithineDrugbanksmall molecule
DB00155 CitrullineDrugbanksmall molecule
DB02011 N-(Phosphonoacetyl)-L-OrnithineDrugbanksmall molecule
DB04185 NorvalineDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
OTC_HUMANTOM20_HUMANBioGRID, HPRD9756929 details