Entity Details

Primary name ANGI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP03950
EntryNameANGI_HUMAN
FullNameAngiogenin
TaxID9606
Evidenceevidence at protein level
Length147
SequenceStatuscomplete
DateCreated1986-10-23
DateModified2021-06-02

Ontological Relatives

GenesANG

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001556 oocyte maturation
GO:0001666 response to hypoxia
GO:0001878 response to yeast
GO:0001890 placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004519 endonuclease activity
GO:0004540 ribonuclease activity
GO:0005102 signaling receptor binding
GO:0005507 copper ion binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0006651 diacylglycerol biosynthetic process
GO:0007154 cell communication
GO:0007202 activation of phospholipase C activity
GO:0008201 heparin binding
GO:0009303 rRNA transcription
GO:0009725 response to hormone
GO:0015629 actin cytoskeleton
GO:0016477 cell migration
GO:0017148 negative regulation of translation
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0019843 rRNA binding
GO:0030041 actin filament polymerization
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0032148 activation of protein kinase B activity
GO:0032311 angiogenin-PRI complex
GO:0032431 activation of phospholipase A2 activity
GO:0034332 adherens junction organization
GO:0042277 peptide binding
GO:0042327 positive regulation of phosphorylation
GO:0042592 homeostatic process
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0045087 innate immune response
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050830 defense response to Gram-positive bacterium
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001427 Pancreatic ribonucleaseFamilyFamily
IPR023411 Ribonuclease A, active siteSiteActive site
IPR023412 Ribonuclease A-domainDomainDomain
IPR036816 Ribonuclease A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
611895 OMIMAmyotrophic lateral sclerosis 9 (ALS9)A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule