Entity Details

Primary name EDN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05305
EntryNameEDN1_HUMAN
FullNameEndothelin-1
TaxID9606
Evidenceevidence at protein level
Length212
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesEDN1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001516 prostaglandin biosynthetic process
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001701 in utero embryonic development
GO:0001821 histamine secretion
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006874 cellular calcium ion homeostasis
GO:0006885 regulation of pH
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0007589 body fluid secretion
GO:0008284 positive regulation of cell population proliferation
GO:0009953 dorsal/ventral pattern formation
GO:0010193 response to ozone
GO:0010259 multicellular organism aging
GO:0010460 positive regulation of heart rate
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010629 negative regulation of gene expression
GO:0010827 regulation of glucose transmembrane transport
GO:0014032 neural crest cell development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0014824 artery smooth muscle contraction
GO:0014826 vein smooth muscle contraction
GO:0019229 regulation of vasoconstriction
GO:0019233 sensory perception of pain
GO:0019722 calcium-mediated signaling
GO:0030072 peptide hormone secretion
GO:0030133 transport vesicle
GO:0030185 nitric oxide transport
GO:0030195 negative regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0031583 phospholipase D-activating G protein-coupled receptor signaling pathway
GO:0031707 endothelin A receptor binding
GO:0031708 endothelin B receptor binding
GO:0032269 negative regulation of cellular protein metabolic process
GO:0032308 positive regulation of prostaglandin secretion
GO:0032496 response to lipopolysaccharide
GO:0033093 Weibel-Palade body
GO:0033574 response to testosterone
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0034696 response to prostaglandin F
GO:0035094 response to nicotine
GO:0035690 cellular response to drug
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0035994 response to muscle stretch
GO:0042045 epithelial fluid transport
GO:0042310 vasoconstriction
GO:0042313 protein kinase C deactivation
GO:0042474 middle ear morphogenesis
GO:0042482 positive regulation of odontogenesis
GO:0042554 superoxide anion generation
GO:0043179 rhythmic excitation
GO:0043200 response to amino acid
GO:0043406 positive regulation of MAP kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0044321 response to leptin
GO:0045178 basal part of cell
GO:0045321 leukocyte activation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045793 positive regulation of cell size
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045987 positive regulation of smooth muscle contraction
GO:0046887 positive regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048016 inositol phosphate-mediated signaling
GO:0048237 rough endoplasmic reticulum lumen
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051216 cartilage development
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0051899 membrane depolarization
GO:0051930 regulation of sensory perception of pain
GO:0060137 maternal process involved in parturition
GO:0060298 positive regulation of sarcomere organization
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070101 positive regulation of chemokine-mediated signaling pathway
GO:0071277 cellular response to calcium ion
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071375 cellular response to peptide hormone stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071389 cellular response to mineralocorticoid stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071548 response to dexamethasone
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0086100 endothelin receptor signaling pathway
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902074 response to salt
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:2000273 positive regulation of signaling receptor activity

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001928 Endothelin-like toxinDomainDomain
IPR019764 Endothelin-like toxin, conserved siteSiteConserved site
IPR020475 EndothelinFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
615706 OMIMAuriculocondylar syndrome 3 (ARCND3)A craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. The disease is caused by variants affecting the gene represented in this entry.
612798 OMIMQuestion mark ears, isolated (QME)An auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB05407 TBC-3711Drugbanksmall molecule