Entity Details

Primary name TRBM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07204
EntryNameTRBM_HUMAN
FullNameThrombomodulin
TaxID9606
Evidenceevidence at protein level
Length575
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesTHBD

GO terms

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GOName
GO:0004888 transmembrane signaling receptor activity
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005774 vacuolar membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007565 female pregnancy
GO:0007596 blood coagulation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010165 response to X-ray
GO:0010544 negative regulation of platelet activation
GO:0016327 apicolateral plasma membrane
GO:0030195 negative regulation of blood coagulation
GO:0032496 response to lipopolysaccharide
GO:0038023 signaling receptor activity
GO:0050900 leukocyte migration
GO:0051591 response to cAMP
GO:0051918 negative regulation of fibrinolysis

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001304 C-type lectin-likeDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR015149 Thrombomodulin-like, EGF-likeDomainDomain
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR016316 ThrombomodulinFamilyFamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00055 Drotrecogin alfaDrugbankbiotech
DB01050 IbuprofenDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
TRBM_HUMANTHRB_HUMANBioGRID, HPRD, IntAct14691232 2544585 7615164 8663147 details
TRBM_HUMANPEN2_HUMANBioGRID, IntAct21988832 details
TRBM_HUMANTMX2_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANTM86B_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANEBP_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANCYBC1_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANGPX8_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANNACHO_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANAIG1_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANS19A3_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANEMC5_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANCIDEB_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANPDZ1I_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANPHF24_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANRHBD2_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANAPOC4_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANKI2L3_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANF209A_HUMANBioGRID, IntAct32296183 details
TRBM_HUMANPLF4_HUMANBioGRID, HPRD9395524 details
TRBM_HUMANLMNA_HUMANBioGRID24623722 details
TRBM_HUMANFCERG_HUMANBioGRID32296183 details
TRBM_HUMANAPOC2_HUMANBioGRID32296183 details
TRBM_HUMANANGP2_HUMANBioGRID888800000189 details
TRBM_HUMANANGP1_HUMANBioGRID888800000189 details
TRBM_HUMANPROC_HUMANHPRD11106601 12588872 details
TRBM_HUMANIPSP_HUMANHPRD12878585 details