Entity Details

Primary name DPOLA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09884
EntryNameDPOLA_HUMAN
FullNameDNA polymerase alpha catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length1462
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPOLA1

GO terms

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GOName
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000166 nucleotide binding
GO:0000731 DNA synthesis involved in DNA repair
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006269 DNA replication, synthesis of RNA primer
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0016032 viral process
GO:0016363 nuclear matrix
GO:0017076 purine nucleotide binding
GO:0019103 pyrimidine nucleotide binding
GO:0019901 protein kinase binding
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032479 regulation of type I interferon production
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:1902975 mitotic DNA replication initiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR006133 DNA-directed DNA polymerase, family B, exonuclease domainDomainDomain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domainDomainDomain
IPR006172 DNA-directed DNA polymerase, family BFamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR015088 Zinc finger, DNA-directed DNA polymerase, family B, alphaDomainDomain
IPR017964 DNA-directed DNA polymerase, family B, conserved siteSiteConserved site
IPR023211 DNA polymerase, palm domain superfamilyFamilyHomologous superfamily
IPR024647 DNA polymerase alpha catalytic subunit, N-terminal domainDomainDomain
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR038256 DNA polymerase alpha, zinc finger domain superfamilyFamilyHomologous superfamily
IPR042087 DNA polymerase family B, thumb domainFamilyHomologous superfamily
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00242 CladribineDrugbanksmall molecule
DB00631 ClofarabineDrugbanksmall molecule
DB01073 FludarabineDrugbanksmall molecule
DB01280 NelarabineDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
DPOLA_HUMANDPOA2_HUMANBioGRID, HPRD, IntAct12138179 22863883 22939629 26344197 8223465 details
DPOLA_HUMANPRI2_HUMANBioGRID, IntAct12138179 22593576 22863883 22939629 28757209 details
DPOLA_HUMANRBMS1_HUMANBioGRID10869558 details
DPOLA_HUMANCDKA1_HUMANBioGRID, HPRD10877824 details
DPOLA_HUMANCDK2_HUMANBioGRID, HPRD10877824 11259605 details
DPOLA_HUMANCDC45_HUMANBioGRID, HPRD10518787 details
DPOLA_HUMANPARP1_HUMANBioGRID, HPRD9518481 9563011 details
DPOLA_HUMANHELB_HUMANBioGRID, HPRD12181327 details
DPOLA_HUMANSLD5_HUMANBioGRID21705323 details
DPOLA_HUMANCCNA2_HUMANBioGRID11259605 details
DPOLA_HUMANCCNB1_HUMANBioGRID11259605 details
DPOLA_HUMANCDK1_HUMANBioGRID, HPRD11259605 details
DPOLA_HUMANRAD51_HUMANBioGRID28757209 details
DPOLA_HUMANSUMO2_HUMANBioGRID32786267 details
DPOLA_HUMANPRI1_HUMANBioGRID, IntAct12138179 22593576 22939629 26344197 28514442 details
DPOLA_HUMANSMC1A_HUMANBioGRID, HPRD, IntAct16438930 details
DPOLA_HUMANRFA1_HUMANBioGRID, MINT17666013 24332808 details
DPOLA_HUMANH31_HUMANBioGRID, IntAct29568061 30104407 details
DPOLA_HUMANRB_HUMANBioGRID, HPRD9395244 details
DPOLA_HUMANXRCC5_HUMANBioGRID, HPRD12393188 details
DPOLA_HUMANP53_HUMANBioGRID, HPRD11917009 details
DPOLA_HUMANCHK1_HUMANBioGRID19177015 details
DPOLA_HUMANCCNE1_HUMANBioGRID11259605 details
DPOLA_HUMANPP2AA_HUMANBioGRID11259605 details
DPOLA_HUMAN2AAB_HUMANBioGRID11259605 details
DPOLA_HUMANMCM2_HUMANBioGRID11259605 details
DPOLA_HUMANDPOE1_HUMANBioGRID, HPRD26344197 9563011 details
DPOLA_HUMANH4_HUMANBioGRID30104407 details
DPOLA_HUMANAACT_HUMANHPRD3490907 details