Entity Details

Primary name CO4A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP0C0L4
EntryNameCO4A_HUMAN
FullNameComplement C4-A
TaxID9606
Evidenceevidence at protein level
Length1744
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesC4A
C4B

GO terms

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GOName
GO:0001849 complement component C1q complex binding
GO:0004866 endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0030424 axon
GO:0030425 dendrite
GO:0030449 regulation of complement activation
GO:0043025 neuronal cell body
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:2000427 positive regulation of apoptotic cell clearance

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Secreted

Domains

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DomainNameCategoryType
IPR000020 Anaphylatoxin/fibulinDomainDomain
IPR001134 Netrin domainDomainDomain
IPR001599 Alpha-2-macroglobulinDomainDomain
IPR001840 Anaphylatoxin, complement system domainDomainDomain
IPR002890 Macroglobulin domainDomainDomain
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-foldFamilyHomologous superfamily
IPR009048 Alpha-macroglobulin, receptor-bindingDomainDomain
IPR011625 Alpha-2-macroglobulin, bait region domainDomainDomain
IPR011626 Alpha-macroglobulin-like, TED domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR018081 Anaphylatoxin, complement systemFamilyHomologous superfamily
IPR018933 Netrin module, non-TIMP typeDomainDomain
IPR019742 Alpha-2-macroglobulin, conserved siteSiteConserved site
IPR036595 Alpha-macroglobulin, receptor-binding domain superfamilyFamilyHomologous superfamily
IPR037569 Complement component C4-AFamilyFamily
IPR040839 Macroglobulin domain MG4DomainDomain
IPR041555 Macroglobulin domain MG3DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00028 Human immunoglobulin GDrugbankbiotech