Entity Details

Primary name PERE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11678
EntryNamePERE_HUMAN
FullNameEosinophil peroxidase
TaxID9606
Evidenceevidence at protein level
Length715
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesEPX

GO terms

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GOName
GO:0002215 defense response to nematode
GO:0004601 peroxidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006979 response to oxidative stress
GO:0020037 heme binding
GO:0032693 negative regulation of interleukin-10 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032753 positive regulation of interleukin-4 production
GO:0034774 secretory granule lumen
GO:0042742 defense response to bacterium
GO:0042744 hydrogen peroxide catabolic process
GO:0043312 neutrophil degranulation
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:0072677 eosinophil migration

Subcellular Location

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Subcellular Location
Cytoplasmic granule

Domains

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DomainNameCategoryType
IPR010255 Haem peroxidase superfamilyFamilyHomologous superfamily
IPR019791 Haem peroxidase, animal-typeFamilyFamily
IPR029599 Eosinophil peroxidaseFamilyFamily
IPR037120 Haem peroxidase domain superfamily, animal typeFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
261500 OMIMEosinophil peroxidase deficiency (EPXD)A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01065 MelatoninDrugbanksmall molecule

Interactions

4 interactions