Entity Details

Primary name SC6A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23975
EntryNameSC6A2_HUMAN
FullNameSodium-dependent noradrenaline transporter
TaxID9606
Evidenceevidence at protein level
Length617
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesSLC6A2

GO terms

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GOName
GO:0003779 actin binding
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005330 dopamine:sodium symporter activity
GO:0005334 norepinephrine:sodium symporter activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006836 neurotransmitter transport
GO:0007268 chemical synaptic transmission
GO:0008504 monoamine transmembrane transporter activity
GO:0009986 cell surface
GO:0015844 monoamine transport
GO:0015874 norepinephrine transport
GO:0016020 membrane
GO:0032809 neuronal cell body membrane
GO:0035725 sodium ion transmembrane transport
GO:0042493 response to drug
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043014 alpha-tubulin binding
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048265 response to pain
GO:0048487 beta-tubulin binding
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051620 norepinephrine uptake
GO:0070050 neuron cellular homeostasis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000175 Sodium:neurotransmitter symporterFamilyFamily
IPR002435 Sodium:neurotransmitter symporter, noradrenalineFamilyFamily
IPR037272 Sodium:neurotransmitter symporter superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
604715 OMIMOrthostatic intolerance (OI)Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00191 PhentermineDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00226 GuanadrelDrugbanksmall molecule
DB00234 ReboxetineDrugbanksmall molecule
DB00245 BenzatropineDrugbanksmall molecule
DB00285 VenlafaxineDrugbanksmall molecule
DB00289 AtomoxetineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00344 ProtriptylineDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00422 MethylphenidateDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00476 DuloxetineDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00579 MazindolDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00830 PhenmetrazineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00937 DiethylpropionDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01104 SertralineDrugbanksmall molecule
DB01105 SibutramineDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01170 GuanethidineDrugbanksmall molecule
DB01173 OrphenadrineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01364 EphedrineDrugbanksmall molecule
DB01381 Ginkgo bilobaDrugbankbiotech
DB01442 MMDADrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB01579 PhendimetrazineDrugbanksmall molecule
DB04821 NomifensineDrugbanksmall molecule
DB04836 AmineptineDrugbanksmall molecule
DB04840 DebrisoquineDrugbanksmall molecule
DB04889 BicifadineDrugbanksmall molecule
DB04896 MilnacipranDrugbanksmall molecule
DB05012 XEN2174Drugbanksmall molecule
DB05642 DDP-225Drugbanksmall molecule
DB05688 CRx-119Drugbanksmall molecule
DB05964 AmitifadineDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06156 TesofensineDrugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06333 TrodusquemineDrugbanksmall molecule
DB06700 DesvenlafaxineDrugbanksmall molecule
DB06701 DexmethylphenidateDrugbanksmall molecule
DB06704 IobenguaneSwissprotsmall molecule
DB08918 LevomilnacipranDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09185 ViloxazineDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB09363 Rauwolfia serpentina rootDrugbanksmall molecule
DB09546 Iobenguane sulfate I-123Swissprotsmall molecule
DB12305 DasotralineDrugbanksmall molecule
DB13931 NetarsudilDrugbanksmall molecule
DB14754 SolriamfetolDrugbanksmall molecule