Entity Details

Primary name PK3CA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42336
EntryNamePK3CA_HUMAN
FullNamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length1068
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPIK3CA

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001889 liver development
GO:0001944 vasculature development
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0005944 phosphatidylinositol 3-kinase complex, class IB
GO:0006006 glucose metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0010468 regulation of gene expression
GO:0010592 positive regulation of lamellipodium assembly
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030295 protein kinase activator activity
GO:0030835 negative regulation of actin filament depolymerization
GO:0031295 T cell costimulation
GO:0032008 positive regulation of TOR signaling
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035994 response to muscle stretch
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0043276 anoikis
GO:0043457 regulation of cellular respiration
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043542 endothelial cell migration
GO:0043560 insulin receptor substrate binding
GO:0044029 hypomethylation of CpG island
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0052742 phosphatidylinositol kinase activity
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0060612 adipose tissue development
GO:0071333 cellular response to glucose stimulus
GO:0071464 cellular response to hydrostatic pressure
GO:0086003 cardiac muscle cell contraction
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110053 regulation of actin filament organization
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000653 regulation of genetic imprinting
GO:2000811 negative regulation of anoikis

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainDomainDomain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domainDomainDomain
IPR002420 C2 phosphatidylinositol 3-kinase-type domainDomainDomain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015433 Phosphatidylinositol kinaseFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR037704 PI3Kalpha, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
612918 OMIMCongenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE)A sporadically occurring, non-hereditary disorder characterized by asymmetric somatic hypertrophy and anomalies in multiple organs. It is defined by four main clinical findings: congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal/spinal abnormalities. The presence of truncal overgrowth and characteristic patterned macrodactyly at birth differentiates CLOVE from other syndromic forms of overgrowth. The disease is caused by variants affecting the gene represented in this entry.
602501 OMIMMegalencephaly-capillary malformation-polymicrogyria syndrome (MCAP)A syndrome characterized by a spectrum of anomalies including primary megalencephaly, prenatal overgrowth, brain and body asymmetry, cutaneous vascular malformations, digital anomalies consisting of syndactyly with or without postaxial polydactyly, connective tissue dysplasia involving the skin, subcutaneous tissue, and joints, and cortical brain malformations, most distinctively polymicrogyria. The disease is caused by variants affecting the gene represented in this entry.
615108 OMIMCowden syndrome 5 (CWS5)A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. The disease is caused by variants affecting the gene represented in this entry.
182000 OMIMKeratosis, seborrheic (KERSEB)A common benign skin tumor. Seborrheic keratoses usually begin with the appearance of one or more sharply defined, light brown, flat macules. The lesions may be sparse or numerous. As they initially grow, they develop a velvety to finely verrucous surface, followed by an uneven warty surface with multiple plugged follicles and a dull or lackluster appearance. The disease is caused by variants affecting the gene represented in this entry.
613089 OMIMCLAPO syndrome (CLAPO)A syndrome characterized by capillary malformation of the lower lip, lymphatic malformation of the face and neck, asymmetry of face and limbs and partial or generalised overgrowth. The disease may be caused by variants affecting the gene represented in this entry. The tissue distribution of the clinical manifestations in CLAPO seems to follow a pattern of somatic mosaicism.
155500 OMIMMacrodactyly (MADAC)A congenital anomaly characterized by fibrofatty tissue enlargement and bony overgrowth affecting the digits or the entire hand or foot. The disease may be caused by variants affecting the gene represented in this entry. The tissue distribution of the clinical manifestations in MADAC seems to follow a pattern of somatic mosaicism.
114550 OMIMHepatocellular carcinoma (HCC)A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. The gene represented in this entry may be involved in disease pathogenesis.
167000 OMIMOvarian cancer (OC)The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Disease susceptibility is associated with variants affecting the gene represented in this entry.
114500 OMIMColorectal cancer (CRC)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. The gene represented in this entry may be involved in disease pathogenesis.
114480 OMIMBreast cancer (BC)A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB05241 XL765Drugbanksmall molecule
DB08059 WortmanninDrugbanksmall molecule
DB11772 PilaralisibDrugbanksmall molecule
DB12015 AlpelisibDrugbanksmall molecule
DB12483 CopanlisibDrugbanksmall molecule

Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
PK3CA_HUMANIRS1_HUMANBioGRID, IntAct, MINT12933652 14511371 16150444 16354680 23604317 23643389 27684187 details
PK3CA_HUMANP85A_HUMANBioGRID, DIP, HPRD, IntAct, MINT11526404 15377662 15932879 16043515 16135792 18079394 19117013 19574958 19805105 20018188 20713702 22402981 23643389 24657164 25253337 26475863 26496610 26839216 27684187 28205554 32814053 7929193 7957566 9235916 9565634 details
PK3CA_HUMANAMBP_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANATIF1_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANSYVM_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANDDX5_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANDNJB6_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANFRIL_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANITIH1_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANCASL_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANRS20_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANSQSTM_HUMANBioGRID, IntAct18624398 27684187 details
PK3CA_HUMANUFD1_HUMANBioGRID, IntAct18624398 details
PK3CA_HUMANGRB2_HUMANBioGRID, IntAct19380743 21706016 28514442 32814053 9565634 details
PK3CA_HUMANP55G_HUMANBioGRID, HPRD, IntAct22402981 25814554 26496610 28514442 9415396 details
PK3CA_HUMANDP13A_HUMANBioGRID, HPRD, IntAct10490823 25241761 details
PK3CA_HUMANFANCC_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANGLT12_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANRASH_HUMANBioGRID, HPRD, MINT10783161 14724584 24412244 8665852 9150145 details
PK3CA_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANF16P2_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANTMOD1_HUMANBioGRID, MINT24412244 details
PK3CA_HUMANTNF13_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANUMPS_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANBEX1_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANBEX2_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANI13R2_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANIL24_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANHOP2_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANTHRSP_HUMANBioGRID, MINT25640309 details
PK3CA_HUMANIL3RB_HUMANDIP23526884 details
PK3CA_HUMANFOS_HUMANIntAct32814053 details
PK3CA_HUMANHD_HUMANIntAct32814053 details
PK3CA_HUMANATX3_HUMANIntAct32814053 details
PK3CA_HUMANATX1_HUMANIntAct32814053 details
PK3CA_HUMANATR_HUMANBioGRID10608806 details
PK3CA_HUMANGRP3_HUMANBioGRID15213298 details
PK3CA_HUMANRHES_HUMANBioGRID, HPRD14724584 16757351 details
PK3CA_HUMANLCK_HUMANBioGRID, HPRD14583609 8020561 8246987 details
PK3CA_HUMANADAP1_HUMANBioGRID12893243 details
PK3CA_HUMANDGKZ_HUMANBioGRID12890670 details
PK3CA_HUMANRASK_HUMANBioGRID10783161 34079125 details
PK3CA_HUMANSGK1_HUMANBioGRID10357815 details
PK3CA_HUMANTNFL6_HUMANBioGRID19807924 details
PK3CA_HUMANSTAT1_HUMANBioGRID11438544 details
PK3CA_HUMANSMAD2_HUMANBioGRID16806069 details
PK3CA_HUMANSMAD3_HUMANBioGRID16806069 details
PK3CA_HUMANAKT1_HUMANBioGRID19117013 21041639 21816939 25793261 details
PK3CA_HUMANPDK1_HUMANBioGRID21041639 details
PK3CA_HUMANCYH3_HUMANBioGRID21041639 details
PK3CA_HUMANCYH2_HUMANBioGRID21041639 details
PK3CA_HUMANPGFRA_HUMANBioGRID7682895 details
PK3CA_HUMANCSF1R_HUMANBioGRID9380408 details
PK3CA_HUMANNED4L_HUMANBioGRID27339899 details
PK3CA_HUMANEGFR_HUMANBioGRID1845983 25754235 28205554 31959764 8561895 details
PK3CA_HUMANSNX9_HUMANBioGRID17242350 details
PK3CA_HUMANPTN11_HUMANBioGRID26839216 9565634 9660791 details
PK3CA_HUMANTF65_HUMANBioGRID15932879 details
PK3CA_HUMANARAF_HUMANBioGRID28205554 details
PK3CA_HUMANCCND2_HUMANBioGRID28205554 details
PK3CA_HUMANGLIS2_HUMANBioGRID28205554 details
PK3CA_HUMANMYC_HUMANBioGRID28205554 details
PK3CA_HUMANSTK11_HUMANBioGRID28205554 details
PK3CA_HUMANERBB3_HUMANBioGRID, IntAct11546794 19411071 24189400 details
PK3CA_HUMANP85B_HUMANBioGRID, DIP, IntAct19380743 22402981 23604317 25253337 26496610 27684187 details
PK3CA_HUMANCBL_HUMANBioGRID, IntAct11157475 19380743 9119889 details
PK3CA_HUMANPLCG1_HUMANBioGRID, IntAct31585087 8561895 details
PK3CA_HUMANNOTC1_HUMANBioGRID14583609 details
PK3CA_HUMANARHG1_HUMANBioGRID12754211 details
PK3CA_HUMANGNAQ_HUMANBioGRID, HPRD12704201 details
PK3CA_HUMANGELS_HUMANBioGRID11577104 details
PK3CA_HUMAN1433F_HUMANBioGRID11969417 details
PK3CA_HUMANIRS4_HUMANBioGRID, HPRD11912194 details
PK3CA_HUMANUBF1_HUMANBioGRID17332342 details
PK3CA_HUMANWDR5_HUMANBioGRID21531708 details
PK3CA_HUMANTNR1A_HUMANBioGRID15707590 details
PK3CA_HUMANCD28_HUMANBioGRID9915850 details
PK3CA_HUMANIRS2_HUMANBioGRID, HPRD12933652 25879670 9113989 details
PK3CA_HUMANTNR5_HUMANBioGRID12637493 details
PK3CA_HUMANESR1_HUMANBioGRID11029009 24051437 details
PK3CA_HUMANGBB1_HUMANBioGRID19117013 details
PK3CA_HUMANKIT_HUMANBioGRID7691885 details
PK3CA_HUMANRAC1_HUMANBioGRID25819133 details
PK3CA_HUMANPTTG1_HUMANBioGRID15845362 details
PK3CA_HUMANDERL1_HUMANBioGRID28178653 details
PK3CA_HUMANRASN_HUMANBioGRID, HPRD30639242 7820549 8665852 details
PK3CA_HUMANRPGF5_HUMANBioGRID8561895 details
PK3CA_HUMANTRAF6_HUMANBioGRID29729098 details
PK3CA_HUMANPGFRB_HUMANHPRD8702949 details
PK3CA_HUMANKPCD_HUMANHPRD11676480 details
PK3CA_HUMANSH3K1_HUMANHPRD10921882 details
PK3CA_HUMANRASM_HUMANHPRD10803462 details
PK3CA_HUMANGBRB1_HUMANHPRD11606067 details
PK3CA_HUMANAPLP2_HUMANHPRD10490823 details
PK3CA_HUMANIL3_HUMANHPRD9113989 details
PK3CA_HUMANTCAM1_HUMANHPRD15940673 details
PK3CA_HUMANKS6B1_HUMANHPRD11279232 details
PK3CA_HUMANNMDE2_HUMANHPRD10620012 details