Entity Details

Primary name MMP13_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP45452
EntryNameMMP13_HUMAN
FullNameCollagenase 3
TaxID9606
Evidenceevidence at protein level
Length471
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMMP13

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0008270 zinc ion binding
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0060349 bone morphogenesis
GO:1904645 response to amyloid-beta

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028711 Collagenase 3FamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule
DB01996 3-MethylpyridineDrugbanksmall molecule
DB02049 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-AcetamideDrugbanksmall molecule
DB02071 WAY-151693Drugbanksmall molecule
DB02697 HydroxyaminovalineDrugbanksmall molecule
DB03033 4-methoxybenzenesulfinateDrugbanksmall molecule
DB04759 PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE)Drugbanksmall molecule
DB04760 PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE)Drugbanksmall molecule
DB04761 PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE]Drugbanksmall molecule
DB06423 EndostatinDrugbankbiotech
DB07013 TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATEDrugbanksmall molecule
DB07827 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACIDDrugbanksmall molecule
DB08388 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONEDrugbanksmall molecule
DB08490 CTS-1027Drugbanksmall molecule
DB08561 BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATEDrugbanksmall molecule