Entity Details

Primary name MTHFS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49914
EntryNameMTHFS_HUMAN
FullName5-formyltetrahydrofolate cyclo-ligase
TaxID9606
Evidenceevidence at protein level
Length203
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMTHFS

GO terms

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GOName
GO:0005524 ATP binding
GO:0005542 folic acid binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006536 glutamate metabolic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0015942 formate metabolic process
GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity
GO:0035999 tetrahydrofolate interconversion
GO:0046653 tetrahydrofolate metabolic process
GO:0046655 folic acid metabolic process
GO:0046657 folic acid catabolic process
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002698 5-formyltetrahydrofolate cyclo-ligaseFamilyFamily
IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain superfamilyFamilyHomologous superfamily
IPR037171 NagB/RpiA transferase-likeFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
MTHFS_HUMANT22D4_HUMANBioGRID, HPRD, IntAct16189514 details