Entity Details

Primary name HNRPU_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00839
EntryNameHNRPU_HUMAN
FullNameHeterogeneous nuclear ribonucleoprotein U
TaxID9606
Evidenceevidence at protein level
Length825
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesHNRNPU

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000228 nuclear chromosome
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0000776 kinetochore
GO:0000922 spindle pole
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000993 RNA polymerase II complex binding
GO:0001097 TFIIH-class transcription factor complex binding
GO:0001649 osteoblast differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0003779 actin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005813 centrosome
GO:0006325 chromatin organization
GO:0006396 RNA processing
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008143 poly(A) binding
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0009986 cell surface
GO:0016020 membrane
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0017069 snRNA binding
GO:0017130 poly(C) RNA binding
GO:0030496 midbody
GO:0031490 chromatin DNA binding
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032839 dendrite cytoplasm
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0033673 negative regulation of kinase activity
GO:0034046 poly(G) binding
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0036002 pre-mRNA binding
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0044877 protein-containing complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048255 mRNA stabilization
GO:0051301 cell division
GO:0051457 maintenance of protein location in nucleus
GO:0055013 cardiac muscle cell development
GO:0070034 telomerase RNA binding
GO:0070934 CRD-mediated mRNA stabilization
GO:0070937 CRD-mediated mRNA stability complex
GO:0071013 catalytic step 2 spliceosome
GO:0071385 cellular response to glucocorticoid stimulus
GO:0072686 mitotic spindle
GO:0090336 positive regulation of brown fat cell differentiation
GO:0098577 inactive sex chromosome
GO:0098963 dendritic transport of messenger ribonucleoprotein complex
GO:0099122 RNA polymerase II C-terminal domain binding
GO:1901673 regulation of mitotic spindle assembly
GO:1902275 regulation of chromatin organization
GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1902889 protein localization to spindle microtubule
GO:1990023 mitotic spindle midzone
GO:1990280 RNA localization to chromatin
GO:1990498 mitotic spindle microtubule
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:1990845 adaptive thermogenesis
GO:1990904 ribonucleoprotein complex
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:2000648 positive regulation of stem cell proliferation
GO:2000737 negative regulation of stem cell differentiation

Subcellular Location

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Subcellular Location
Cell surface
Chromosome
Cytoplasm
Cytoplasmic granule
Midbody
Nucleus
Nucleus matrix
Nucleus speckle

Domains

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DomainNameCategoryType
IPR001870 B30.2/SPRY domainDomainDomain
IPR003034 SAP domainDomainDomain
IPR003877 SPRY domainDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR026745 Heterogeneous nuclear ribonucleoprotein UFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035778 Heterogeneous nuclear ribonucleoprotein U, SPRY domainDomainDomain
IPR036361 SAP domain superfamilyFamilyHomologous superfamily
IPR043136 B30.2/SPRY domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617391 OMIMDevelopmental and epileptic encephalopathy 54 (DEE54)A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. The disease is caused by variants affecting the gene represented in this entry.

Interactions

107 interactions

InteractorPartnerSourcesPublicationsLink
HNRPU_HUMANRPB1_HUMANBioGRID10490622 15711563 18710935 21235343 details
HNRPU_HUMANTCRG1_HUMANBioGRID16055720 details
HNRPU_HUMANCDN2A_HUMANBioGRID, IntAct21988832 details
HNRPU_HUMANHMGB1_HUMANBioGRID, UniProt29721183 31694235 details
HNRPU_HUMANPO3F4_HUMANHPRD9105675 details
HNRPU_HUMANSMN_HUMANHPRD, MINT8670859 details
HNRPU_HUMANWBP4_HUMANBioGRID, MINT16055720 details
HNRPU_HUMANACTB_HUMANBioGRID, HPRD15711563 18710935 details
HNRPU_HUMANHNRPQ_HUMANBioGRID, IntAct, MINT22365833 22863883 26344197 26496610 details
HNRPU_HUMANTADBP_HUMANBioGRID, IntAct20020773 32814053 details
HNRPU_HUMANPIN1_HUMANBioGRID16055720 details
HNRPU_HUMANKAT2B_HUMANBioGRID18710935 details
HNRPU_HUMANHNRPD_HUMANBioGRID, IntAct, MINT22365833 26318153 26496610 30021884 details
HNRPU_HUMANARF_HUMANBioGRID21988832 details
HNRPU_HUMANEP300_HUMANBioGRID, HPRD11909954 details
HNRPU_HUMANANM1_HUMANBioGRID, HPRD11850402 details
HNRPU_HUMANUBQL2_HUMANBioGRID, UniProt25616961 30442662 details
HNRPU_HUMANJPH3_HUMANIntAct32814053 details
HNRPU_HUMANRBPS2_HUMANBioGRID, IntAct32296183 details
HNRPU_HUMANERG_HUMANBioGRID21575865 24591637 details
HNRPU_HUMANGAS7_HUMANBioGRID, MINT16055720 26506240 details
HNRPU_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
HNRPU_HUMANPR40A_HUMANBioGRID16055720 details
HNRPU_HUMANHNRH3_HUMANBioGRID, MINT22365833 details
HNRPU_HUMANSREK1_HUMANBioGRID, HPRD14559993 details
HNRPU_HUMANSUMO2_HUMANBioGRID32786267 details
HNRPU_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
HNRPU_HUMANNEDD4_HUMANBioGRID16055720 details
HNRPU_HUMANUBC9_HUMANBioGRID19596686 details
HNRPU_HUMANMLP3A_HUMANBioGRID, IntAct20562859 22963397 details
HNRPU_HUMANNOP56_HUMANBioGRID, IntAct12777385 26496610 details
HNRPU_HUMANGLPK3_HUMANIntAct30021884 details
HNRPU_HUMANGOG8C_HUMANIntAct30021884 details
HNRPU_HUMANNECD_HUMANBioGRID, HPRD, MINT11813259 32529326 details
HNRPU_HUMANGCR_HUMANBioGRID, HPRD9353307 details
HNRPU_HUMANFBW1A_HUMANBioGRID, HPRD11850407 20797629 25332235 25900982 27861801 details
HNRPU_HUMANIF2B1_HUMANBioGRID, IntAct19029303 26496610 details
HNRPU_HUMANMYC_HUMANBioGRID19578763 29467282 details
HNRPU_HUMANMO4L1_HUMANBioGRID17573780 details
HNRPU_HUMANDHX9_HUMANBioGRID, HPIDb, IntAct21849455 22751105 22863883 26496610 details
HNRPU_HUMANNPM_HUMANBioGRID, IntAct20431927 22939629 26496610 details
HNRPU_HUMANANM8_HUMANBioGRID, IntAct18320585 26186194 28514442 details
HNRPU_HUMANUBXN6_HUMANBioGRID22337587 details
HNRPU_HUMANU2AF2_HUMANBioGRID22939629 26641092 details
HNRPU_HUMANOBSL1_HUMANBioGRID24711643 details
HNRPU_HUMANERPG3_HUMANBioGRID26030138 26496610 details
HNRPU_HUMANNEMO_HUMANIntAct14743216 details
HNRPU_HUMANBIP_HUMANBioGRID24189400 26344197 details
HNRPU_HUMANCDK7_HUMANBioGRID10490622 17643375 details
HNRPU_HUMANNFX1_HUMANBioGRID17267499 details
HNRPU_HUMANPHF6_HUMANBioGRID22720776 details
HNRPU_HUMANSMC3_HUMANBioGRID31010829 details
HNRPU_HUMANTF2H1_HUMANHPRD10490622 details
HNRPU_HUMANIKKB_HUMANBioGRID, IntAct14743216 20797629 details
HNRPU_HUMANEMD_HUMANBioGRID17620012 23443559 details
HNRPU_HUMANSEML_HUMANBioGRID24515614 details
HNRPU_HUMANNFKB2_HUMANIntAct14743216 details
HNRPU_HUMANDGCR8_HUMANBioGRID17765891 details
HNRPU_HUMANUBS3B_HUMANBioGRID24189400 details
HNRPU_HUMANYAP1_HUMANBioGRID, HPRD15096513 27684187 31501420 details
HNRPU_HUMANNMDE4_HUMANHPRD10862698 details
HNRPU_HUMANNMDZ1_HUMANHPRD10862698 details
HNRPU_HUMANRELB_HUMANIntAct14743216 details
HNRPU_HUMANTNR1B_HUMANIntAct14743216 details
HNRPU_HUMANT2FA_HUMANBioGRID10490622 15711563 details
HNRPU_HUMANITA4_HUMANBioGRID22623428 details
HNRPU_HUMANSEM1_HUMANBioGRID24515614 details
HNRPU_HUMANELL_HUMANHPRD10490622 details
HNRPU_HUMAN1433S_HUMANBioGRID, MINT15778465 details
HNRPU_HUMANERCC6_HUMANBioGRID, IntAct26030138 26496610 details
HNRPU_HUMANMO4L2_HUMANBioGRID17573780 details
HNRPU_HUMANDOT1L_HUMANBioGRID20431927 details
HNRPU_HUMANEIF3H_HUMANBioGRID32269044 details
HNRPU_HUMANKSYK_HUMANHPRD7831290 details
HNRPU_HUMANCASP3_HUMANHPRD10671544 details
HNRPU_HUMANTF65_HUMANIntAct14743216 details
HNRPU_HUMANMAX_HUMANBioGRID19578763 details
HNRPU_HUMANAPEX1_HUMANBioGRID28986522 details
HNRPU_HUMANKDM4B_HUMANBioGRID21502505 details
HNRPU_HUMANCUL7_HUMANBioGRID24711643 details
HNRPU_HUMANM3K14_HUMANIntAct14743216 details
HNRPU_HUMANKAT6B_HUMANIntAct30021884 details
HNRPU_HUMANPML_HUMANBioGRID18212063 details
HNRPU_HUMANMRGBP_HUMANBioGRID17573780 details
HNRPU_HUMANRBM39_HUMANBioGRID16051665 22939629 28302793 details
HNRPU_HUMANZN689_HUMANBioGRID, HPRD16568080 details
HNRPU_HUMANPNKP_HUMANBioGRID15385968 details
HNRPU_HUMANMARCS_HUMANBioGRID22939629 30942445 details
HNRPU_HUMANSF3A2_HUMANBioGRID, MINT17332742 details
HNRPU_HUMANNS1BP_HUMANBioGRID23825951 details
HNRPU_HUMANCENPW_HUMANBioGRID27861801 details
HNRPU_HUMAN1433Z_HUMANMINT15161933 details
HNRPU_HUMANRN146_HUMANBioGRID21825151 details
HNRPU_HUMANGAN_HUMANBioGRID26460568 details
HNRPU_HUMANRARA_HUMANBioGRID18212063 details
HNRPU_HUMANCCDC8_HUMANBioGRID24711643 details
HNRPU_HUMANTANK_HUMANIntAct14743216 details
HNRPU_HUMANIKBA_HUMANBioGRID20797629 details
HNRPU_HUMANSOX2_HUMANBioGRID21280222 details
HNRPU_HUMANCD5_HUMANHPRD9079809 details
HNRPU_HUMANIKBB_HUMANIntAct14743216 details
HNRPU_HUMANSMRCD_HUMANBioGRID21549307 details
HNRPU_HUMANCR2_HUMANHPRD7753047 details
HNRPU_HUMANMACD1_HUMANBioGRID25735744 details
HNRPU_HUMANRN169_HUMANBioGRID28325877 details
HNRPU_HUMANPAX4_HUMANIntAct30021884 details
HNRPU_HUMANPTN11_HUMANHPRD8943344 details