Entity Details

Primary name ROR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01974
EntryNameROR2_HUMAN
FullNameTyrosine-protein kinase transmembrane receptor ROR2
TaxID9606
Evidenceevidence at protein level
Length943
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesROR2

GO terms

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GOName
GO:0001502 cartilage condensation
GO:0001756 somitogenesis
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005109 frizzled binding
GO:0005524 ATP binding
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007224 smoothened signaling pathway
GO:0007254 JNK cascade
GO:0007275 multicellular organism development
GO:0008285 negative regulation of cell population proliferation
GO:0009986 cell surface
GO:0010976 positive regulation of neuron projection development
GO:0014002 astrocyte development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017147 Wnt-protein binding
GO:0030282 bone mineralization
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030509 BMP signaling pathway
GO:0030538 embryonic genitalia morphogenesis
GO:0030539 male genitalia development
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0033674 positive regulation of kinase activity
GO:0042472 inner ear morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043507 positive regulation of JUN kinase activity
GO:0045165 cell fate commitment
GO:0045651 positive regulation of macrophage differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060395 SMAD protein signal transduction
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1900020 positive regulation of protein kinase C activity
GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
GO:1905517 macrophage migration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR016247 Tyrosine-protein kinase, receptor RORFamilyFamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR020067 Frizzled domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
113000 OMIMBrachydactyly B1 (BDB1)A form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type B1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Symphalangism is also a feature. The disease is caused by variants affecting the gene represented in this entry.
268310 OMIMRobinow syndrome, autosomal recessive 1 (RRS1)A recessive form of Robinow syndrome, a disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally far more severe in recessive cases, particularly skeletal abnormalities. All patients with the recessive form suffer from vertebral segmentation abnormalities, resulting in scoliosis and chest deformities. Rib fusions are considered to be characteristic of the autosomal recessive form. Patients can also present brachydactyly, with extensive aplasia/hypoplasia of the phalanges and metacarpals/metatarsals, and brachy-syn-polydactyly of the hands and oligodactyly of the feet. The disease is caused by variants affecting the gene represented in this entry.

Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
ROR2_HUMANPR20D_HUMANBioGRID, IntAct25416956 32296183 details
ROR2_HUMANALG13_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANCA094_HUMANBioGRID, IntAct25416956 30886144 32296183 details
ROR2_HUMANDAZP2_HUMANBioGRID, IntAct18762249 25416956 32296183 details
ROR2_HUMANLHX6_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANCS054_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANKR197_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANSTOX1_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANCJ055_HUMANIntAct32296183 details
ROR2_HUMANBHE40_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANCRX_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ROR2_HUMANOBF1_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANSOX14_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANFOSB_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANAAKB2_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANARI5A_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANPITX1_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANCREM_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANMSX2_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANF168B_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANPA2GX_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANTLX3_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANKRA71_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANCC056_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANVENTX_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANISX_HUMANBioGRID, IntAct32296183 details
ROR2_HUMANSRC_HUMANMINT28065597 details
ROR2_HUMANDUS18_HUMANBioGRID, MINT28065597 details
ROR2_HUMANDUS10_HUMANBioGRID, MINT28065597 details
ROR2_HUMANDUS6_HUMANBioGRID, MINT28065597 details
ROR2_HUMANDUS1_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPTN12_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPTN11_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPTN7_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPP2BB_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPTN6_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPTPRR_HUMANBioGRID, MINT28065597 details
ROR2_HUMANTAB1_HUMANBioGRID, MINT28065597 details
ROR2_HUMANILKAP_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPPM1F_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPPM1A_HUMANBioGRID, MINT28065597 details
ROR2_HUMANPPM1B_HUMANBioGRID, MINT28065597 details
ROR2_HUMANDUS19_HUMANBioGRID, MINT28065597 details
ROR2_HUMANDUS21_HUMANBioGRID, MINT28065597 details
ROR2_HUMANDUS29_HUMANBioGRID, MINT28065597 details
ROR2_HUMANSTYX_HUMANBioGRID, MINT28065597 details
ROR2_HUMANCC14A_HUMANBioGRID, MINT28065597 details
ROR2_HUMANTPTE_HUMANBioGRID, MINT28065597 details
ROR2_HUMANMTMR1_HUMANBioGRID, MINT28065597 details
ROR2_HUMANMTMR6_HUMANBioGRID, MINT28065597 details
ROR2_HUMANMTMR9_HUMANBioGRID, MINT28065597 details
ROR2_HUMANMTMR2_HUMANBioGRID, MINT28065597 details
ROR2_HUMANMPIP3_HUMANBioGRID, MINT28065597 details
ROR2_HUMANEYA2_HUMANBioGRID, MINT28065597 details
ROR2_HUMANDUS14_HUMANBioGRID, MINT28065597 details
ROR2_HUMANMAGD1_HUMANBioGRID, HPRD12754255 details
ROR2_HUMANNEMO_HUMANBioGRID20098747 details
ROR2_HUMANM3K7_HUMANBioGRID18762249 details
ROR2_HUMANDAB1_HUMANBioGRID25416956 details
ROR2_HUMANROR2_HUMANBioGRID25416956 details
ROR2_HUMANZMYM4_HUMANBioGRID25416956 details
ROR2_HUMANRBPMS_HUMANBioGRID25416956 details
ROR2_HUMANPR20E_HUMANBioGRID25416956 32296183 details
ROR2_HUMANPR20C_HUMANBioGRID25416956 32296183 details
ROR2_HUMANPR20B_HUMANBioGRID25416956 32296183 details
ROR2_HUMANPR20A_HUMANBioGRID25416956 32296183 details
ROR2_HUMANPTN20_HUMANBioGRID28065597 details
ROR2_HUMANERBB2_HUMANBioGRID30898150 details
ROR2_HUMANZEP1_HUMANBioGRID32296183 details
ROR2_HUMANTET5A_HUMANBioGRID32296183 details
ROR2_HUMANAT7L1_HUMANBioGRID32296183 details
ROR2_HUMANZNF34_HUMANBioGRID32296183 details
ROR2_HUMANHS90B_HUMANIntAct22939624 details
ROR2_HUMANWNT1_HUMANBioGRID18762249 details
ROR2_HUMANHS90A_HUMANBioGRID22939624 details
ROR2_HUMANWNT5A_HUMANHPRD12839624 details
ROR2_HUMANFZD2_HUMANHPRD12839624 details
ROR2_HUMANFZD5_HUMANHPRD12839624 details