Entity Details

Primary name SYCP2
Entity type gene
Source Source Link

Details

PrimaryID10388
RefseqGeneNG_046980
SymbolSYCP2
Namesynaptonemal complex protein 2
Chromosome20
Location20q13.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-16
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSYCP2_HUMAN

GO terms

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GOName
GO:0000795 synaptonemal complex
GO:0000800 lateral element
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0007130 synaptonemal complex assembly
GO:0007140 male meiotic nuclear division
GO:0007143 female meiotic nuclear division
GO:0009566 fertilization
GO:0043066 negative regulation of apoptotic process
GO:0048808 male genitalia morphogenesis
GO:0051301 cell division
GO:0140013 meiotic nuclear division

Diseases

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Disease IDSourceNameDescription
258150 OMIMSpermatogenic failure 1 (SPGF1)An infertility disorder characterized by azoospermia due to spermatogenic arrest during meiosis. Meiotic arrest is characterized by germ cells that enter meiosis and undergo the first chromosomal reduction from 4n to 2n, but that are then unable to proceed further. This results in tubules containing spermatocytes as the latest developmental stage of germ cells. Meiotically arrested spermatocytes accumulate in the tubules and degenerate. Both autosomal recessive and autosomal dominant inheritance have been reported. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
SYCP2SRPK2BioGRID26167880 details
SYCP2HORMAD2BioGRID30657449 details
SYCP2SYCP3BioGRID30657449 details