Entity Details

Primary name DNAI1
Entity type gene
Source Source Link

Details

PrimaryID27019
RefseqGeneNG_008127
SymbolDNAI1
Namedynein axonemal intermediate chain 1
Chromosome9
Location9p13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-20
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsDNAI1_HUMAN

GO terms

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GOName
GO:0003341 cilium movement
GO:0003774 cytoskeletal motor activity
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005929 cilium
GO:0007018 microtubule-based movement
GO:0007368 determination of left/right symmetry
GO:0030317 flagellated sperm motility
GO:0036157 outer dynein arm
GO:0036158 outer dynein arm assembly
GO:0045503 dynein light chain binding
GO:0045504 dynein heavy chain binding

Diseases

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Disease IDSourceNameDescription
244400 OMIMCiliary dyskinesia, primary, 1 (CILD1)A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. The disease is caused by variants affecting the gene represented in this entry.
244400 OMIMCiliary dyskinesia, primary, 1 (CILD1)A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
DNAI1SQSTM1BioGRID25015291 details
DNAI1HIF1ABioGRID22367210 details
DNAI1PAFAH1B1HPRD11889140 details