Entity Details

Primary name DOA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06340
EntryNameDOA_HUMAN
FullNameHLA class II histocompatibility antigen, DO alpha chain
TaxID9606
Evidenceevidence at protein level
Length250
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesHLA-DOA

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 MHC class II protein complex binding
GO:0032395 MHC class II receptor activity
GO:0042613 MHC class II protein complex
GO:0045580 regulation of T cell differentiation

Subcellular Location

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Subcellular Location
Endosome membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR001003 MHC class II, alpha chain, N-terminalDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014745 MHC class II, alpha/beta chain, N-terminalFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DOA_HUMANREL_HUMANBioGRID, IntAct25416956 details
DOA_HUMANDOB_HUMANDIP23222639 details