Entity Details

Primary name TCAM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IUC6
EntryNameTCAM1_HUMAN
FullNameTIR domain-containing adapter molecule 1
TaxID9606
Evidenceevidence at protein level
Length712
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GenesTICAM1

GO terms

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GOName
GO:0002281 macrophage activation involved in immune response
GO:0002735 positive regulation of myeloid dendritic cell cytokine production
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005739 mitochondrion
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010008 endosome membrane
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0019901 protein kinase binding
GO:0030890 positive regulation of B cell proliferation
GO:0031398 positive regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032092 positive regulation of protein binding
GO:0032722 positive regulation of chemokine production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein-containing complex assembly
GO:0043330 response to exogenous dsRNA
GO:0045087 innate immune response
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0070266 necroptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0097190 apoptotic signaling pathway
GO:0097342 ripoptosome
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Mitochondrion

Domains

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DomainNameCategoryType
IPR017278 TIR domain-containing adapter molecule 1FamilyFamily
IPR025735 RHIM domainDomainDomain
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily
IPR040886 TRIF, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
614850 OMIMEncephalopathy, acute, infection-induced, Herpes-specific, 6 (IIAE6)A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
TCAM1_HUMANTCAM2_HUMANBioGRID, HPRD, IntAct12721283 14519765 25736436 31511519 details
TCAM1_HUMANSRSF4_HUMANBioGRID, IntAct21988832 details
TCAM1_HUMANSARM1_HUMANIntAct26592460 details
TCAM1_HUMANTRAF2_HUMANBioGRID14982987 19795416 20047764 details
TCAM1_HUMANTRAF6_HUMANBioGRID, HPRD14530355 14982987 15474016 19795416 20047764 24812060 25736436 details
TCAM1_HUMANUBQL1_HUMANBioGRID21695056 details
TCAM1_HUMANTRAF1_HUMANBioGRID, HPRD14982987 16323247 19795416 details
TCAM1_HUMANTLR3_HUMANBioGRID, HPRD12539043 14982987 25736436 27810922 31511519 details
TCAM1_HUMANIRF3_HUMANBioGRID, HPRD14739303 25636800 details
TCAM1_HUMANTRIM8_HUMANBioGRID28747347 details
TCAM1_HUMANIRF7_HUMANHPRD14739303 details
TCAM1_HUMANTNAP3_HUMANBioGRID, HPRD, MINT15474016 details
TCAM1_HUMANPIAS4_HUMANBioGRID, HPRD, MINT15251447 details
TCAM1_HUMANTBK1_HUMANBioGRID, DIP, HPRD, IntAct, UniProt14530355 15841462 19416887 19656901 21903422 25736436 28049150 28747347 31511519 details
TCAM1_HUMANTRI56_HUMANBioGRID, IntAct22948160 details
TCAM1_HUMANRIPK1_HUMANBioGRID, HPRD15064760 19734906 25736436 33052227 details
TCAM1_HUMANRIPK3_HUMANBioGRID, HPRD15064760 details
TCAM1_HUMANRN216_HUMANBioGRID16968706 details
TCAM1_HUMANTLR4_HUMANBioGRID19656901 25736436 31511519 details
TCAM1_HUMANCBLB_HUMANBioGRID20639876 details
TCAM1_HUMANTRAF3_HUMANBioGRID, HPRD14982987 16306936 16306937 17991829 24577058 28747347 31511519 details
TCAM1_HUMANTRAF5_HUMANBioGRID14982987 details
TCAM1_HUMANTRAF4_HUMANBioGRID, HPRD16052631 details
TCAM1_HUMANMAVS_HUMANBioGRID, HPRD16153868 details
TCAM1_HUMANTRI38_HUMANBioGRID23056470 details
TCAM1_HUMANKSYK_HUMANBioGRID23962979 details
TCAM1_HUMANTCAM1_HUMANBioGRID24577058 details
TCAM1_HUMANCASP8_HUMANBioGRID21737330 33052227 details
TCAM1_HUMANCFLAR_HUMANBioGRID21737330 details
TCAM1_HUMANFOSL1_HUMANBioGRID28049150 details
TCAM1_HUMANABCF1_HUMANBioGRID30770245 details
TCAM1_HUMANUBP19_HUMANBioGRID31511519 details
TCAM1_HUMANBACD3_HUMANBioGRID31511519 details
TCAM1_HUMANR144B_HUMANBioGRID31509299 details
TCAM1_HUMANPELI1_HUMANBioGRID33052227 details
TCAM1_HUMANTRAM1_HUMANHPRD12721283 details
TCAM1_HUMANPK3CA_HUMANHPRD15940673 details
TCAM1_HUMANTLR2_HUMANHPRD12471095 details
TCAM1_HUMANIKKE_HUMANHPRD12692549 details
TCAM1_HUMANTIRAP_HUMANHPRD14517278 details
TCAM1_HUMANAZI2_HUMANHPRD15611223 details