Entity Details

Primary name ABCA7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IZY2
EntryNameABCA7_HUMAN
FullNamePhospholipid-transporting ATPase ABCA7
TaxID9606
Evidenceevidence at protein level
Length2146
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesABCA7

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001891 phagocytic cup
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0007613 memory
GO:0008542 visual learning
GO:0009986 cell surface
GO:0010875 positive regulation of cholesterol efflux
GO:0016021 integral component of membrane
GO:0018149 peptide cross-linking
GO:0019216 regulation of lipid metabolic process
GO:0030054 cell junction
GO:0031901 early endosome membrane
GO:0032587 ruffle membrane
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034188 apolipoprotein A-I receptor activity
GO:0034205 amyloid-beta formation
GO:0034380 high-density lipoprotein particle assembly
GO:0034504 protein localization to nucleus
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043409 negative regulation of MAPK cascade
GO:0044857 plasma membrane raft organization
GO:0045332 phospholipid translocation
GO:0045806 negative regulation of endocytosis
GO:0050766 positive regulation of phagocytosis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0097386 glial cell projection
GO:0140328 floppase activity
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1900223 positive regulation of amyloid-beta clearance
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1902430 negative regulation of amyloid-beta formation
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902995 positive regulation of phospholipid efflux
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:2000010 positive regulation of protein localization to cell surface

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Early endosome membrane
Endoplasmic reticulum
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR026082 ABC transporter AFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030369 ATP-binding cassette subfamily A member 7FamilyFamily

Diseases

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Disease IDSourceNameDescription
608907 OMIMAlzheimer disease 9 (AD9)A familial, late-onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ABCA7_HUMANADRB2_HUMANBioGRID, MINT28298427 details
ABCA7_HUMANC5AR2_HUMANBioGRID, MINT28298427 details