Entity Details

Primary name DIC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBX3
EntryNameDIC_HUMAN
FullNameMitochondrial dicarboxylate carrier
TaxID9606
Evidenceevidence at protein level
Length287
SequenceStatuscomplete
DateCreated2002-02-11
DateModified2021-06-02

Ontological Relatives

GenesSLC25A10

GO terms

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GOName
GO:0005310 dicarboxylic acid transmembrane transporter activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006094 gluconeogenesis
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0006839 mitochondrial transport
GO:0008272 sulfate transport
GO:0015116 sulfate transmembrane transporter activity
GO:0015117 thiosulfate transmembrane transporter activity
GO:0015131 oxaloacetate transmembrane transporter activity
GO:0015140 malate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015709 thiosulfate transport
GO:0015729 oxaloacetate transport
GO:0016021 integral component of membrane
GO:0035435 phosphate ion transmembrane transport
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase
GO:0071422 succinate transmembrane transport
GO:0071423 malate transmembrane transport

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR002030 Mitochondrial carrier UCP-likeFamilyFamily
IPR018108 Mitochondrial substrate/solute carrierRepeatRepeat
IPR023395 Mitochondrial carrier domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618972 OMIMMitochondrial DNA depletion syndrome 19 (MTDPS19)An autosomal recessive mitochondrial disorder characterized by progressive and severe epileptic encephalopathy, hypotonia, poor spontaneous movements evolving to spastic quadriparesis and dyskinesias, and respiratory complex I deficiency and mitochondrial DNA depletion in skeletal muscle. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00139 Succinic acidDrugbanksmall molecule