Entity Details

Primary name CD2AP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5K6
EntryNameCD2AP_HUMAN
FullNameCD2-associated protein
TaxID9606
Evidenceevidence at protein level
Length639
SequenceStatuscomplete
DateCreated2003-04-23
DateModified2021-06-02

Ontological Relatives

GenesCD2AP

GO terms

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GOName
GO:0001650 fibrillar center
GO:0001726 ruffle
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005200 structural constituent of cytoskeleton
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007015 actin filament organization
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0015629 actin cytoskeleton
GO:0016050 vesicle organization
GO:0017124 SH3 domain binding
GO:0030139 endocytic vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0031941 filamentous actin
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0034451 centriolar satellite
GO:0042802 identical protein binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044877 protein-containing complex binding
GO:0045296 cadherin binding
GO:0048259 regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0050714 positive regulation of protein secretion
GO:0051058 negative regulation of small GTPase mediated signal transduction
GO:0051301 cell division
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0098609 cell-cell adhesion
GO:1900182 positive regulation of protein localization to nucleus
GO:2000249 regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR028445 CD2-associated proteinFamilyFamily
IPR035775 CD2-associated protein, first SH3 domainDomainDomain
IPR035776 CD2-associated protein, second SH3 domainDomainDomain
IPR035777 CD2-associated protein, third SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
607832 OMIMFocal segmental glomerulosclerosis 3 (FSGS3)A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
CD2AP_HUMANCBL_HUMANBioGRID, HPRD, IntAct, MINT11067845 12559036 12618476 12672817 15128873 17020880 17072306 17188587 22706086 25036637 25872741 details
CD2AP_HUMANCD2_HUMANBioGRID, HPRD, MINT12618476 12690097 17020880 23663663 9741631 details
CD2AP_HUMANABL1_HUMANIntAct17474147 details
CD2AP_HUMANFYN_HUMANHPRD, IntAct10339567 17474147 31413325 details
CD2AP_HUMANCBLB_HUMANBioGRID, MINT17020880 23663663 details
CD2AP_HUMANCD2AP_HUMANBioGRID, HPRD, IntAct, MINT10339567 12559036 17020880 31413325 details
CD2AP_HUMANGRB2_HUMANBioGRID, HPRD, IntAct10339567 19380743 21706016 21988832 details
CD2AP_HUMANNR4A1_HUMANBioGRID, IntAct18654987 details
CD2AP_HUMANNR2C2_HUMANBioGRID, IntAct18654987 details
CD2AP_HUMANHBP1_HUMANBioGRID, IntAct18654987 details
CD2AP_HUMANHXC11_HUMANBioGRID, IntAct18654987 details
CD2AP_HUMANTEBP_HUMANBioGRID, IntAct21988832 details
CD2AP_HUMANKHDR1_HUMANBioGRID, IntAct22745667 31413325 details
CD2AP_HUMANSH3G2_HUMANBioGRID, IntAct12672817 31413325 details
CD2AP_HUMANRIN3_HUMANBioGRID, IntAct32552912 details
CD2AP_HUMANRAB4A_HUMANBioGRID, HPRD12559036 details
CD2AP_HUMANCAZA1_HUMANBioGRID, HPRD12690097 20697350 22706086 details
CD2AP_HUMANPODO_HUMANBioGRID, HPRD11733557 20457601 details
CD2AP_HUMANBCAR1_HUMANBioGRID, HPRD10339567 12618476 details
CD2AP_HUMANSRC8_HUMANBioGRID12672817 details
CD2AP_HUMANUBC_HUMANBioGRID24039852 details
CD2AP_HUMANGRAB_HUMANBioGRID17283187 details
CD2AP_HUMANUBC9_HUMANBioGRID22203040 details
CD2AP_HUMANARAP3_HUMANBioGRID17314030 details
CD2AP_HUMANPKD2_HUMANHPRD10913159 details
CD2AP_HUMANHCK_HUMANHPRD, MINT12029088 details
CD2AP_HUMANSOS1_HUMANBioGRID, HPRD, IntAct14679214 32203420 details
CD2AP_HUMANSOS2_HUMANHPRD, IntAct14679214 details
CD2AP_HUMANPDC6I_HUMANBioGRID, HPRD, IntAct, MINT17428861 17853893 31413325 details
CD2AP_HUMANTS101_HUMANBioGRID, MINT17853893 details
CD2AP_HUMANBLNK_HUMANBioGRID, MINT21822214 details
CD2AP_HUMANIQGA1_HUMANIntAct22662192 details
CD2AP_HUMANCAZA2_HUMANBioGRID, IntAct20697350 26186194 26496610 28514442 details
CD2AP_HUMANSH3K1_HUMANBioGRID, IntAct17606992 20457601 28514442 31142511 31413325 31980649 details
CD2AP_HUMANDCTN1_HUMANIntAct31413325 details
CD2AP_HUMANDEND_HUMANIntAct31413325 details
CD2AP_HUMANANS1A_HUMANIntAct31413325 details
CD2AP_HUMANMACF1_HUMANIntAct31413325 details
CD2AP_HUMANASAP1_HUMANBioGRID, IntAct15632162 31413325 details
CD2AP_HUMANMBIP1_HUMANIntAct31413325 details
CD2AP_HUMANUACA_HUMANIntAct31413325 details
CD2AP_HUMANANS1B_HUMANIntAct31413325 details
CD2AP_HUMANRU17_HUMANIntAct31413325 details
CD2AP_HUMANTRIM8_HUMANIntAct31413325 details
CD2AP_HUMANSYNJ2_HUMANIntAct31413325 details
CD2AP_HUMANMB12A_HUMANBioGRID, HPRD, IntAct16895919 17853893 20654576 31413325 details
CD2AP_HUMANRHG17_HUMANBioGRID, IntAct16678097 32203420 details
CD2AP_HUMANNPHN_HUMANBioGRID, HPRD10997929 20457601 details
CD2AP_HUMANACTC_HUMANBioGRID17606992 details
CD2AP_HUMANEGFR_HUMANBioGRID12672817 details
CD2AP_HUMANDYN2_HUMANBioGRID12672817 details
CD2AP_HUMANSHIP1_HUMANBioGRID22706086 details
CD2AP_HUMANCAPZB_HUMANBioGRID20697350 22706086 details
CD2AP_HUMANCBLC_HUMANBioGRID18753381 details
CD2AP_HUMAN3BP1_HUMANBioGRID20697350 32203420 details
CD2AP_HUMANLYOX_HUMANBioGRID24167568 details
CD2AP_HUMANFRS3_HUMANBioGRID23279575 details
CD2AP_HUMANSHIP2_HUMANBioGRID17314030 details
CD2AP_HUMANAKT1_HUMANBioGRID24462114 details
CD2AP_HUMANIRS1_HUMANBioGRID29729186 details
CD2AP_HUMANYES_HUMANHPRD10339567 details
CD2AP_HUMANP85A_HUMANHPRD10339567 details
CD2AP_HUMANSRC_HUMANHPRD10339567 details
CD2AP_HUMANPPIP1_HUMANHPRD12530983 details
CD2AP_HUMANWTIP_HUMANHPRD14736876 details