Entity Details

Primary name NOL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60936
EntryNameNOL3_HUMAN
FullNameNucleolar protein 3
TaxID9606
Evidenceevidence at protein level
Length208
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesNOL3

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001974 blood vessel remodeling
GO:0002931 response to ischemia
GO:0003723 RNA binding
GO:0005123 death receptor binding
GO:0005509 calcium ion binding
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006376 mRNA splice site selection
GO:0008380 RNA splicing
GO:0010659 cardiac muscle cell apoptotic process
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014736 negative regulation of muscle atrophy
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014876 response to injury involved in regulation of muscle adaptation
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0035877 death effector domain binding
GO:0042802 identical protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051259 protein complex oligomerization
GO:0060547 negative regulation of necrotic cell death
GO:0089720 caspase binding
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Nucleus
Sarcoplasmic reticulum

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614937 OMIMMyoclonus, familial, 1 (MYOCL1)An autosomal dominant neurologic condition characterized by adult onset of cortical myoclonus manifest as involuntary jerks or movements affecting the face and limbs. Affected individuals can also experience falls without seizure activity or loss of consciousness. The disease is caused by variants affecting the gene represented in this entry.