Entity Details

Primary name KPCG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05129
EntryNameKPCG_HUMAN
FullNameProtein kinase C gamma type
TaxID9606
Evidenceevidence at protein level
Length697
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesPRKCG

GO terms

Show/Hide Table
GOName
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0007268 chemical synaptic transmission
GO:0007611 learning or memory
GO:0007635 chemosensory behavior
GO:0008270 zinc ion binding
GO:0009636 response to toxic substance
GO:0014069 postsynaptic density
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030168 platelet activation
GO:0030425 dendrite
GO:0031397 negative regulation of protein ubiquitination
GO:0032095 regulation of response to food
GO:0032425 positive regulation of mismatch repair
GO:0035556 intracellular signal transduction
GO:0042177 negative regulation of protein catabolic process
GO:0042752 regulation of circadian rhythm
GO:0043278 response to morphine
GO:0043524 negative regulation of neuron apoptotic process
GO:0044305 calyx of Held
GO:0046777 protein autophosphorylation
GO:0048265 response to pain
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0050764 regulation of phagocytosis
GO:0060291 long-term synaptic potentiation
GO:0060384 innervation
GO:0097060 synaptic membrane
GO:0099171 presynaptic modulation of chemical synaptic transmission
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901799 negative regulation of proteasomal protein catabolic process
GO:1990911 response to psychosocial stress
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014375 Protein kinase C, alpha/beta/gamma typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
605361 OMIMSpinocerebellar ataxia 14 (SCA14)Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA). The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
KPCG_HUMANPICK1_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANNOXA1_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANEXOC5_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANCCHCR_HUMANBioGRID, HPRD, IntAct16713569 details
KPCG_HUMANPTN1_HUMANMINT17092689 details
KPCG_HUMANSAMD3_HUMANIntAct32814053 details
KPCG_HUMANTCP1L_HUMANIntAct32814053 details
KPCG_HUMANF167A_HUMANIntAct32814053 details
KPCG_HUMANPIAS1_HUMANIntAct32814053 details
KPCG_HUMANK1C19_HUMANIntAct32814053 details
KPCG_HUMANGRIA4_HUMANBioGRID, HPRD12471040 details
KPCG_HUMANRGS2_HUMANBioGRID, HPRD11063746 details
KPCG_HUMANTIAM1_HUMANBioGRID, HPRD10212259 details
KPCG_HUMANAFAP1_HUMANBioGRID, HPRD12134071 details
KPCG_HUMANDDX58_HUMANBioGRID22114345 details
KPCG_HUMANTOP2A_HUMANBioGRID, HPRD12569090 7499337 details
KPCG_HUMANA4_HUMANBioGRID21832049 details
KPCG_HUMANSDC2_HUMANBioGRID, HPRD9244383 details
KPCG_HUMANITB2_HUMANBioGRID11700305 details
KPCG_HUMANGSK3A_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
KPCG_HUMANCASR_HUMANBioGRID, HPRD9694886 details
KPCG_HUMANARHGP_HUMANBioGRID20395553 details
KPCG_HUMANRBP10_HUMANBioGRID20395553 details
KPCG_HUMANGFAP_HUMANBioGRID20395553 details
KPCG_HUMANHSP74_HUMANBioGRID20395553 details
KPCG_HUMANEPHB1_HUMANBioGRID20395553 details
KPCG_HUMANSCN3A_HUMANBioGRID20395553 details
KPCG_HUMANTRIM5_HUMANBioGRID20395553 details
KPCG_HUMANDAB2_HUMANBioGRID, HPRD10542228 details
KPCG_HUMANCTNB1_HUMANBioGRID25639486 details
KPCG_HUMANSMUF1_HUMANBioGRID20804422 details
KPCG_HUMANUBE2T_HUMANBioGRID28162934 details
KPCG_HUMANFBX7_HUMANBioGRID27503909 details
KPCG_HUMANDNJC5_HUMANBioGRID29167402 details
KPCG_HUMANARHG7_HUMANBioGRID29167402 details
KPCG_HUMANTAU_HUMANBioGRID11104762 details
KPCG_HUMANPDLI5_HUMANHPRD8940095 details
KPCG_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
KPCG_HUMAN1433G_HUMANBioGRID, HPRD10433554 details
KPCG_HUMANGBRA1_HUMANBioGRID, HPRD12091471 details
KPCG_HUMANGBRA4_HUMANBioGRID, HPRD12091471 details
KPCG_HUMANIBTK_HUMANBioGRID21482705 details
KPCG_HUMANRANB9_HUMANBioGRID20395553 details
KPCG_HUMANVTNC_HUMANHPRD9030777 details
KPCG_HUMAN1433B_HUMANHPRD14676191 details
KPCG_HUMANPA2G4_HUMANHPRD11325528 details
KPCG_HUMANNEUG_HUMANHPRD8080473 details
KPCG_HUMANCYH2_HUMANHPRD10531036 details
KPCG_HUMANNMDE4_HUMANHPRD10862698 details
KPCG_HUMANOCLN_HUMANHPRD11502742 details
KPCG_HUMANSTXB1_HUMANHPRD12519779 12950453 8631738 details
KPCG_HUMANPNMA1_HUMANHPRD14676191 details
KPCG_HUMANPARD3_HUMANHPRD14676191 details
KPCG_HUMANPAR6A_HUMANHPRD14676191 details
KPCG_HUMANPEBP1_HUMANHPRD12551925 14654844 details
KPCG_HUMANMARK4_HUMANHPRD14676191 details
KPCG_HUMANHABP4_HUMANHPRD14699138 details
KPCG_HUMANNMDZ1_HUMANHPRD10862698 details
KPCG_HUMANPP14A_HUMANHPRD15003508 details
KPCG_HUMANPAR6B_HUMANHPRD14676191 details
KPCG_HUMANARBK1_HUMANHPRD11042191 details
KPCG_HUMANGRM5_HUMANHPRD15894802 details
KPCG_HUMANCDC42_HUMANHPRD14676191 details
KPCG_HUMANCLAT_HUMANHPRD15381704 details
KPCG_HUMANCXA3_HUMANHPRD15467523 details
KPCG_HUMANIRS1_HUMANHPRD15364919 details
KPCG_HUMANANXA7_HUMANHPRD11278415 details
KPCG_HUMANCXA1_HUMANHPRD10871288 details
KPCG_HUMANDVL2_HUMANHPRD12958364 details
KPCG_HUMAN1433E_HUMANHPRD15459208 details
KPCG_HUMANNUMB_HUMANHPRD17203073 details
KPCG_HUMANIF4E_HUMANHPRD8662663 details
KPCG_HUMANNMDE2_HUMANHPRD11306676 12147342 8940188 details
KPCG_HUMANCD5_HUMANHPRD11123317 details