Entity Details

Primary name PGS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07585
EntryNamePGS2_HUMAN
FullNameDecorin
TaxID9606
Evidenceevidence at protein level
Length359
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesDCN

GO terms

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GOName
GO:0001822 kidney development
GO:0001890 placenta development
GO:0003723 RNA binding
GO:0005518 collagen binding
GO:0005539 glycosaminoglycan binding
GO:0005576 extracellular region
GO:0005589 collagen type VI trimer
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0007519 skeletal muscle tissue development
GO:0007568 aging
GO:0009612 response to mechanical stimulus
GO:0009887 animal organ morphogenesis
GO:0010508 positive regulation of autophagy
GO:0010596 negative regulation of endothelial cell migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016239 positive regulation of macroautophagy
GO:0016525 negative regulation of angiogenesis
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030021 extracellular matrix structural constituent conferring compression resistance
GO:0030198 extracellular matrix organization
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0032496 response to lipopolysaccharide
GO:0042060 wound healing
GO:0043202 lysosomal lumen
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0047485 protein N-terminus binding
GO:0050840 extracellular matrix binding
GO:0051901 positive regulation of mitochondrial depolarization
GO:0062023 collagen-containing extracellular matrix
GO:0090141 positive regulation of mitochondrial fission
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000372 Leucine-rich repeat N-terminal domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycanFamilyFamily
IPR028549 DecorinFamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
610048 OMIMCorneal dystrophy, congenital stromal (CSCD)A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. The disease is caused by variants affecting the gene represented in this entry.

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
PGS2_HUMANINSR_HUMANmatrixdb24389353 details
PGS2_HUMANIGF2_HUMANmatrixdb24389353 details
PGS2_HUMANINS_HUMANmatrixdb24389353 details
PGS2_HUMANFGF2_HUMANmatrixdb24447999 details
PGS2_HUMANFINC_HUMANHPRD, matrixdb1468447 1747115 details
PGS2_HUMANXYLK_HUMANIntAct25331875 25789606 details
PGS2_HUMANBMP1_HUMANIntAct20026052 details
PGS2_HUMANEGFR_HUMANBioGRID, HPRD12105206 9988678 details
PGS2_HUMANSFTPD_HUMANBioGRID, HPRD12730206 details
PGS2_HUMANCOEA1_HUMANBioGRID, HPRD9252349 details
PGS2_HUMANFLNA_HUMANBioGRID, HPRD12106908 details
PGS2_HUMANTGFB1_HUMANBioGRID, HPRD7638106 7798269 8093006 9675033 details
PGS2_HUMANTNFA_HUMANBioGRID, HPRD12387878 details
PGS2_HUMANELN_HUMANBioGRID, HPRD11723132 details
PGS2_HUMANC1QA_HUMANBioGRID, HPRD1431141 details
PGS2_HUMANCO6A1_HUMANBioGRID1544908 details
PGS2_HUMANTGFB2_HUMANBioGRID9675033 details
PGS2_HUMANFETUA_HUMANBioGRID, HPRD12071714 details
PGS2_HUMANPA2GA_HUMANBioGRID, HPRD10747008 details
PGS2_HUMANMET_HUMANBioGRID19433454 details
PGS2_HUMANBRCA1_HUMANBioGRID22990118 details
PGS2_HUMANCO5A1_HUMANHPRD8440685 details
PGS2_HUMANDERM_HUMANHPRD9895299 details
PGS2_HUMANCO4A3_HUMANHPRD10382266 details
PGS2_HUMANCO4A1_HUMANHPRD10382266 details
PGS2_HUMANCO4A4_HUMANHPRD10382266 details
PGS2_HUMANCO1A1_HUMANHPRD1468447 9675033 details
PGS2_HUMANCO1A2_HUMANHPRD1468447 2375748 9675033 details
PGS2_HUMANMMP2_HUMANHPRD9148753 details
PGS2_HUMANMMP3_HUMANHPRD9148753 details
PGS2_HUMANFBN1_HUMANHPRD10793130 details
PGS2_HUMANMMP7_HUMANHPRD9148753 details
PGS2_HUMANTSP1_HUMANHPRD1550960 9328841 details
PGS2_HUMANCO4A5_HUMANHPRD10382266 details
PGS2_HUMANCO4A6_HUMANHPRD10382266 details
PGS2_HUMANCCN4_HUMANHPRD11598131 details