Entity Details

Primary name MIP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30301
EntryNameMIP_HUMAN
FullNameLens fiber major intrinsic protein
TaxID9606
Evidenceevidence at protein level
Length263
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesMIP

GO terms

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GOName
GO:0002088 lens development in camera-type eye
GO:0005212 structural constituent of eye lens
GO:0005516 calmodulin binding
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0006833 water transport
GO:0007601 visual perception
GO:0015250 water channel activity
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0045785 positive regulation of cell adhesion
GO:0050896 response to stimulus
GO:0051289 protein homotetramerization
GO:1990349 gap junction-mediated intercellular transport

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000425 Major intrinsic proteinFamilyFamily
IPR022357 Major intrinsic protein, conserved siteSiteConserved site
IPR023271 Aquaporin-likeFamilyHomologous superfamily
IPR034294 Aquaporin transporterFamilyFamily

Diseases

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Disease IDSourceNameDescription
615274 OMIMCataract 15, multiple types (CTRCT15)An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT15 includes polymorphic, progressive punctate lamellar, cortical, anterior and posterior polar, nonprogressive lamellar with sutural opacities, embryonic nuclear, and pulverulent cortical, among others. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB02451 B-nonylglucosideDrugbanksmall molecule

Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
MIP_HUMANSAR1A_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSYCY2_HUMANBioGRID, IntAct32296183 details
MIP_HUMANLRP10_HUMANIntAct32296183 details
MIP_HUMANT4S18_HUMANIntAct32296183 details
MIP_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
MIP_HUMANAMGO1_HUMANIntAct32296183 details
MIP_HUMANTNR5_HUMANBioGRID, IntAct32296183 details
MIP_HUMANGOLM1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANGPX8_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSYT2_HUMANBioGRID, IntAct32296183 details
MIP_HUMANAQP9_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSYT1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSYAP1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANPDZ1I_HUMANBioGRID, IntAct32296183 details
MIP_HUMANVMAT1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANCLD5_HUMANBioGRID, IntAct32296183 details
MIP_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANUT1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANTM154_HUMANBioGRID, IntAct32296183 details
MIP_HUMANRT18B_HUMANBioGRID, IntAct32296183 details
MIP_HUMANRELL2_HUMANBioGRID, IntAct32296183 details
MIP_HUMANTMX2_HUMANBioGRID, IntAct32296183 details
MIP_HUMANTM139_HUMANBioGRID, IntAct32296183 details
MIP_HUMANFCG2A_HUMANBioGRID, IntAct32296183 details
MIP_HUMANMGST3_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSSMM1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANKCNJ6_HUMANBioGRID, IntAct32296183 details
MIP_HUMANVATO_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSTX2_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSTX1A_HUMANBioGRID, IntAct32296183 details
MIP_HUMANMFF_HUMANBioGRID, IntAct32296183 details
MIP_HUMANCISD2_HUMANBioGRID, IntAct32296183 details
MIP_HUMANCXB5_HUMANBioGRID, IntAct32296183 details
MIP_HUMANSGPL1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANF209A_HUMANBioGRID, IntAct32296183 details
MIP_HUMANLHPL5_HUMANBioGRID, IntAct32296183 details
MIP_HUMANMRM3_HUMANBioGRID, IntAct32296183 details
MIP_HUMANTM52B_HUMANBioGRID, IntAct32296183 details
MIP_HUMANZFPL1_HUMANBioGRID, IntAct32296183 details
MIP_HUMANLRC4C_HUMANBioGRID, IntAct32296183 details
MIP_HUMANHSP72_HUMANIntAct32814053 details
MIP_HUMANCALM1_HUMANBioGRID, HPRD1790714 2487274 details
MIP_HUMANCALM2_HUMANBioGRID, HPRD1790714 2487274 details
MIP_HUMANCALM3_HUMANBioGRID, HPRD1790714 2487274 details
MIP_HUMANCRYA2_HUMANBioGRID, HPRD18004741 8910261 details
MIP_HUMANCRYAA_HUMANBioGRID, HPRD18004741 8910261 details
MIP_HUMANCRYAB_HUMANBioGRID18004741 details
MIP_HUMANCRBB2_HUMANBioGRID18004741 details
MIP_HUMANCRGC_HUMANBioGRID18004741 details
MIP_HUMANLMNA_HUMANBioGRID24623722 details
MIP_HUMANCXA3_HUMANHPRD9664032 details
MIP_HUMANMIP_HUMANHPRD8529419 details
MIP_HUMANFOXA2_HUMANHPRD12642491 details
MIP_HUMANCXA8_HUMANHPRD9664032 details
MIP_HUMANKAPCA_HUMANHPRD2176601 details