Entity Details

Primary name TCPE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48643
EntryNameTCPE_HUMAN
FullNameT-complex protein 1 subunit epsilon
TaxID9606
Evidenceevidence at protein level
Length541
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCCT5

GO terms

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GOName
GO:0003730 mRNA 3'-UTR binding
GO:0005524 ATP binding
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0009615 response to virus
GO:0016887 ATP hydrolysis activity
GO:0031681 G-protein beta-subunit binding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0044183 protein folding chaperone
GO:0044297 cell body
GO:0048027 mRNA 5'-UTR binding
GO:0048487 beta-tubulin binding
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0070062 extracellular exosome
GO:1901998 toxin transport
GO:1904851 positive regulation of establishment of protein localization to telomere
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002194 Chaperonin TCP-1, conserved siteSiteConserved site
IPR002423 Chaperonin Cpn60/TCP-1 familyFamilyFamily
IPR012718 T-complex protein 1, epsilon subunitFamilyFamily
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)FamilyFamily
IPR027409 GroEL-like apical domain superfamilyFamilyHomologous superfamily
IPR027410 TCP-1-like chaperonin intermediate domain superfamilyFamilyHomologous superfamily
IPR027413 GroEL-like equatorial domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
256840 OMIMNeuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)A disease characterized by spastic paraplegia and progressive distal sensory neuropathy leading to mutilating ulcerations of the upper and lower limbs. The disease is caused by variants affecting the gene represented in this entry.

Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
TCPE_HUMANELP1_HUMANBioGRID, HPRD, IntAct16169070 details
TCPE_HUMANXRN1_HUMANBioGRID, HPRD, IntAct15231747 details
TCPE_HUMANP53_HUMANBioGRID, HPRD, IntAct, MINT16169070 22653443 23443559 25144556 31152661 details
TCPE_HUMANMIC60_HUMANBioGRID, HPRD, IntAct16169070 details
TCPE_HUMANTBC17_HUMANBioGRID, HPRD, IntAct16169070 details
TCPE_HUMANZNRD2_HUMANBioGRID, HPRD, IntAct16189514 22939629 25416956 32296183 details
TCPE_HUMANHDAC3_HUMANBioGRID, HPRD, IntAct12502735 23752268 details
TCPE_HUMANOGT1_HUMANBioGRID, IntAct27705803 32994395 details
TCPE_HUMANHXA1_HUMANIntAct32814053 details
TCPE_HUMANPIAS1_HUMANIntAct32814053 details
TCPE_HUMANTIM8A_HUMANIntAct32814053 details
TCPE_HUMANWWP2_HUMANIntAct32814053 details
TCPE_HUMANNPFF_HUMANIntAct32814053 details
TCPE_HUMANHXK3_HUMANIntAct32814053 details
TCPE_HUMANSTABP_HUMANIntAct32814053 details
TCPE_HUMANCSN3_HUMANIntAct32814053 details
TCPE_HUMANBAG3_HUMANIntAct32814053 details
TCPE_HUMANBECN1_HUMANIntAct32814053 details
TCPE_HUMANSTAM2_HUMANIntAct32814053 details
TCPE_HUMANFBXL2_HUMANIntAct32814053 details
TCPE_HUMANVDAC2_HUMANIntAct32814053 details
TCPE_HUMANGCP4_HUMANIntAct32814053 details
TCPE_HUMANLONF2_HUMANIntAct32814053 details
TCPE_HUMANGFOD1_HUMANIntAct32814053 details
TCPE_HUMANSHOX2_HUMANIntAct32814053 details
TCPE_HUMANHYPM_HUMANIntAct32814053 details
TCPE_HUMANZN641_HUMANIntAct32814053 details
TCPE_HUMANLHX8_HUMANIntAct32814053 details
TCPE_HUMANKT33B_HUMANIntAct32814053 details
TCPE_HUMANCL074_HUMANIntAct32814053 details
TCPE_HUMANSEM4G_HUMANIntAct32814053 details
TCPE_HUMANRNF38_HUMANIntAct32814053 details
TCPE_HUMANARFG3_HUMANIntAct32814053 details
TCPE_HUMANCSN7B_HUMANIntAct32814053 details
TCPE_HUMANESRP1_HUMANIntAct32814053 details
TCPE_HUMANPGRP3_HUMANIntAct32814053 details
TCPE_HUMANSPAG8_HUMANIntAct32814053 details
TCPE_HUMANPHLP_HUMANBioGRID, HPRD15889144 details
TCPE_HUMANTHEG_HUMANBioGRID, HPRD10747865 details
TCPE_HUMANHD_HUMANIntAct32814053 details
TCPE_HUMANUBE2W_HUMANIntAct32814053 details
TCPE_HUMANCDC20_HUMANBioGRID23443559 25306918 26811472 28096334 details
TCPE_HUMANATX1_HUMANIntAct32814053 details
TCPE_HUMANERCC6_HUMANBioGRID31722399 details
TCPE_HUMANSUMO2_HUMANBioGRID32786267 details
TCPE_HUMANTERT_HUMANBioGRID23741361 details
TCPE_HUMANMCPH1_HUMANBioGRID29150431 details
TCPE_HUMANERPG3_HUMANBioGRID31722399 details
TCPE_HUMANIKKE_HUMANBioGRID, IntAct14743216 25852190 details
TCPE_HUMANM3K1_HUMANIntAct14743216 details
TCPE_HUMANTBK1_HUMANIntAct14743216 details
TCPE_HUMANM3K3_HUMANIntAct14743216 details
TCPE_HUMANTCPA_HUMANBioGRID, HPRD, IntAct16085932 16097032 22939629 26344197 9250675 details
TCPE_HUMANDCAF7_HUMANBioGRID, IntAct25342745 27705803 28514442 details
TCPE_HUMANRIPK3_HUMANIntAct14743216 details
TCPE_HUMANACTA_HUMANBioGRID, HPRD11580270 details
TCPE_HUMANSRRM1_HUMANBioGRID16159877 details
TCPE_HUMANRGS7_HUMANBioGRID19376773 details
TCPE_HUMANFGF11_HUMANBioGRID28027390 details
TCPE_HUMANF86B2_HUMANBioGRID23349634 details
TCPE_HUMAN2ABA_HUMANBioGRID19156129 details
TCPE_HUMANACTB_HUMANBioGRID, HPRD11580269 details
TCPE_HUMANVHL_HUMANBioGRID17339318 21942715 details
TCPE_HUMANSIR6_HUMANBioGRID24169447 details
TCPE_HUMANGNB5_HUMANBioGRID19376773 details
TCPE_HUMANSMAP2_HUMANBioGRID29395067 details
TCPE_HUMANGAN_HUMANBioGRID26460568 details
TCPE_HUMANACTS_HUMANBioGRID, HPRD11580270 details
TCPE_HUMANNLE1_HUMANBioGRID26472760 details
TCPE_HUMANHEY1_HUMANBioGRID27129302 details
TCPE_HUMANCOP1_HUMANBioGRID16497536 details
TCPE_HUMANSRRM2_HUMANBioGRID16159877 details
TCPE_HUMANWDR82_HUMANBioGRID20516061 details
TCPE_HUMANHDAC5_HUMANBioGRID21081666 details
TCPE_HUMANGBB1_HUMANBioGRID19376773 details
TCPE_HUMANPACRG_HUMANBioGRID14532270 details
TCPE_HUMANEFMT3_HUMANBioGRID23349634 details
TCPE_HUMANTTC27_HUMANBioGRID26472760 details
TCPE_HUMANERCC8_HUMANBioGRID29531219 details
TCPE_HUMANSUMO4_HUMANHPRD16236267 details