Entity Details

Primary name DRD3
Entity type gene
Source Source Link

Details

PrimaryID1814
RefseqGeneNG_008842
SymbolDRD3
Namedopamine receptor D3
Chromosome3
Location3q13.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1992-06-17
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsDRD3_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0002031 G protein-coupled receptor internalization
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006914 autophagy
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007611 learning or memory
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell population proliferation
GO:0008542 visual learning
GO:0014059 regulation of dopamine secretion
GO:0019904 protein domain specific binding
GO:0030139 endocytic vesicle
GO:0031748 D1 dopamine receptor binding
GO:0032416 negative regulation of sodium:proton antiporter activity
GO:0032467 positive regulation of cytokinesis
GO:0032922 circadian regulation of gene expression
GO:0034776 response to histamine
GO:0035176 social behavior
GO:0035483 gastric emptying
GO:0035815 positive regulation of renal sodium excretion
GO:0042220 response to cocaine
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042995 cell projection
GO:0043066 negative regulation of apoptotic process
GO:0043266 regulation of potassium ion transport
GO:0043278 response to morphine
GO:0045177 apical part of cell
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045776 negative regulation of blood pressure
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046717 acid secretion
GO:0048148 behavioral response to cocaine
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0050883 musculoskeletal movement, spinal reflex action
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0051898 negative regulation of protein kinase B signaling
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060134 prepulse inhibition
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090325 regulation of locomotion involved in locomotory behavior
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1901386 negative regulation of voltage-gated calcium channel activity

Diseases

Show/Hide Table
Disease IDSourceNameDescription
181500 OMIMSchizophrenia (SCZD)A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Disease susceptibility may be associated with variants affecting the gene represented in this entry.
190300 OMIMTremor, hereditary essential 1 (ETM1)A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Disease susceptibility is associated with variants affecting the gene represented in this entry.