Entity Details

Primary name RPGF6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TEU7
EntryNameRPGF6_HUMAN
FullNameRap guanine nucleotide exchange factor 6
TaxID9606
Evidenceevidence at protein level
Length1601
SequenceStatuscomplete
DateCreated2003-08-29
DateModified2021-06-02

Ontological Relatives

GenesRAPGEF6

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007265 Ras protein signal transduction
GO:0016324 apical plasma membrane
GO:0030033 microvillus assembly
GO:0030139 endocytic vesicle
GO:0030742 GTP-dependent protein binding
GO:0031267 small GTPase binding
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0070300 phosphatidic acid binding
GO:0072659 protein localization to plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000159 Ras-associating (RA) domainDomainDomain
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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