Entity Details

Primary name ACON_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99798
EntryNameACON_HUMAN
FullNameAconitate hydratase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length780
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesACO2

GO terms

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GOName
GO:0003994 aconitate hydratase activity
GO:0005506 iron ion binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006091 generation of precursor metabolites and energy
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0047780 citrate dehydratase activity
GO:0051539 4 iron, 4 sulfur cluster binding

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domainDomainDomain
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domainDomainDomain
IPR006248 Aconitase, mitochondrial-likeFamilyFamily
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivelFamilyHomologous superfamily
IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3FamilyHomologous superfamily
IPR015932 Aconitase, domain 2FamilyHomologous superfamily
IPR018136 Aconitase family, 4Fe-4S cluster binding siteSiteBinding site
IPR036008 Aconitase, iron-sulfur domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01727 Isocitric AcidDrugbanksmall molecule
DB03964 4-Hydroxy-Aconitate IonDrugbanksmall molecule
DB04072 Alpha-Methylisocitric AcidDrugbanksmall molecule
DB04351 Aconitate IonDrugbanksmall molecule
DB04562 Tricarballylic acidDrugbanksmall molecule