Entity Details

Primary name PDE10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y233
EntryNamePDE10_HUMAN
FullNamecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
TaxID9606
Evidenceevidence at protein level
Length779
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesPDE10A

GO terms

Show/Hide Table
GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005829 cytosol
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0030552 cAMP binding
GO:0030553 cGMP binding
GO:0046069 cGMP catabolic process
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003018 GAF domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR029016 GAF-like domain superfamilyFamilyHomologous superfamily
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00975 DipyridamoleDrugbanksmall molecule
DB01113 PapaverineDrugbanksmall molecule
DB08383 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazoleDrugbanksmall molecule
DB08384 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinolineDrugbanksmall molecule
DB08386 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinolineDrugbanksmall molecule
DB08387 MardepodectDrugbanksmall molecule
DB08389 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINEDrugbanksmall molecule
DB08391 PQ-10Drugbanksmall molecule
DB08811 TofisopamDrugbanksmall molecule
DB08814 TriflusalDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule

Interactions

3 interactions