Entity Details

Primary name POLH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y253
EntryNamePOLH_HUMAN
FullNameDNA polymerase eta
TaxID9606
Evidenceevidence at protein level
Length713
SequenceStatuscomplete
DateCreated2005-02-15
DateModified2021-06-02

Ontological Relatives

GenesPOLH

GO terms

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GOName
GO:0000731 DNA synthesis involved in DNA repair
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006290 pyrimidine dimer repair
GO:0009314 response to radiation
GO:0010225 response to UV-C
GO:0019985 translesion synthesis
GO:0035861 site of double-strand break
GO:0042276 error-prone translesion synthesis
GO:0046872 metal ion binding
GO:0070987 error-free translesion synthesis
GO:0071494 cellular response to UV-C

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001126 UmuC domainDomainDomain
IPR017961 DNA polymerase, Y-family, little finger domainDomainDomain
IPR036775 DNA polymerase, Y-family, little finger domain superfamilyFamilyHomologous superfamily
IPR041298 DNA polymerase eta, ubiquitin-binding zinc fingerDomainDomain
IPR043128 Reverse transcriptase/Diguanylate cyclase domainFamilyHomologous superfamily
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
POLH_HUMANUBC_HUMANBioGRID, MINT16357261 16763556 17304240 20129057 25766642 31699778 details
POLH_HUMANPOLH_HUMANMINT16763556 details
POLH_HUMANREV1_HUMANBioGRID, HPRD, MINT15189446 15380106 16824193 19170759 21690293 22691049 22828282 details
POLH_HUMANPALB2_HUMANBioGRID, UniProt24485656 details
POLH_HUMANBRCA2_HUMANBioGRID, UniProt24485656 details
POLH_HUMANPCNA_HUMANBioGRID, HPRD11585903 15149598 15342632 16763556 20129057 20159558 21791603 21855803 22989887 23042605 23345618 23388460 23761444 24474685 25766642 26988343 27770570 28831681 30563767 30963698 31796584 details
POLH_HUMANRAD18_HUMANBioGRID15359278 16824193 21098111 21396873 23345618 29590477 details
POLH_HUMANZN363_HUMANBioGRID20008555 21791603 details
POLH_HUMANPOLI_HUMANBioGRID, HPRD12426396 12606586 16763556 23248005 details
POLH_HUMANMLH1_HUMANBioGRID19703417 details
POLH_HUMANA4_HUMANBioGRID21832049 details
POLH_HUMANTRAIP_HUMANBioGRID24553286 details
POLH_HUMANUBP7_HUMANBioGRID25435364 31796584 details
POLH_HUMANDPOD2_HUMANBioGRID25662213 details
POLH_HUMANWBP2_HUMANBioGRID27578003 details
POLH_HUMANTBA1B_HUMANBioGRID16824193 details
POLH_HUMANTBB5_HUMANBioGRID16824193 details
POLH_HUMANUBE2B_HUMANBioGRID16824193 details
POLH_HUMANHS90A_HUMANBioGRID20129057 details
POLH_HUMANMDM2_HUMANBioGRID22056306 details
POLH_HUMANSPRTN_HUMANBioGRID22902628 details
POLH_HUMANBRCA1_HUMANBioGRID23901102 details
POLH_HUMANFACD2_HUMANBioGRID23388460 details
POLH_HUMANSART3_HUMANBioGRID29590477 details
POLH_HUMANUBR5_HUMANBioGRID31586398 details
POLH_HUMANH2A1B_HUMANBioGRID31586398 details
POLH_HUMANDYL1_HUMANHPRD14760703 details
POLH_HUMANRS27A_HUMANHPRD17304240 details