Entity Details

Primary name UCHL5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y5K5
EntryNameUCHL5_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase isozyme L5
TaxID9606
Evidenceevidence at protein level
Length329
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesUCHL5

GO terms

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GOName
GO:0000502 proteasome complex
GO:0003723 RNA binding
GO:0004843 thiol-dependent deubiquitinase
GO:0004866 endopeptidase inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:0031011 Ino80 complex
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045880 positive regulation of smoothened signaling pathway
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070628 proteasome binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR017390 Ubiquitinyl hydrolase, UCH37 typeFamilyFamily
IPR033837 Ubiquitinyl hydrolase-L5DomainDomain
IPR036959 Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR041507 Peptidase C12, C-terminal domainDomainDomain

Diseases

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Interactions

120 interactions

InteractorPartnerSourcesPublicationsLink
UCHL5_HUMANADRM1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt16501559 16906146 16990800 17139257 18922472 19490896 19615732 20471946 21516116 22863883 24752541 25416956 25702870 26186194 26344197 27107012 28198400 28442575 28514442 28598414 30217970 31515488 32631902 details
UCHL5_HUMANPSMD4_HUMANBioGRID, IntAct, MINT, UniProt17139257 18922472 19490896 19615732 22863883 26186194 28514442 details
UCHL5_HUMANPSMD8_HUMANBioGRID, HPRD, IntAct, UniProt11163772 18922472 19490896 19615732 22863883 26186194 28514442 details
UCHL5_HUMANNFRKB_HUMANBioGRID, IntAct, UniProt17721549 18922472 19615732 24981860 25194926 25416956 25702870 25702872 26186194 28514442 32296183 32351584 details
UCHL5_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
UCHL5_HUMANZBED1_HUMANBioGRID, IntAct25416956 details
UCHL5_HUMANUBE3A_HUMANBioGRID, IntAct22645313 24743594 26186194 28514442 29426014 details
UCHL5_HUMANHAUS7_HUMANBioGRID11163772 details
UCHL5_HUMANSMAD2_HUMANBioGRID16027725 details
UCHL5_HUMANSMAD3_HUMANBioGRID16027725 27604640 details
UCHL5_HUMANSMAD7_HUMANBioGRID16027725 details
UCHL5_HUMANUBC_HUMANBioGRID16196087 22284438 25702870 27066941 28190767 28338014 28935764 29576527 details
UCHL5_HUMANBIP_HUMANBioGRID21800051 details
UCHL5_HUMANARGI1_HUMANBioGRID21800051 details
UCHL5_HUMANCASPE_HUMANBioGRID21800051 details
UCHL5_HUMANH4_HUMANBioGRID21800051 30804502 details
UCHL5_HUMANSET_HUMANBioGRID21800051 details
UCHL5_HUMANDSC1_HUMANBioGRID21800051 details
UCHL5_HUMANAPRV1_HUMANBioGRID21800051 details
UCHL5_HUMANK2C80_HUMANBioGRID21800051 details
UCHL5_HUMANPOF1B_HUMANBioGRID21800051 details
UCHL5_HUMANACTN4_HUMANBioGRID21800051 details
UCHL5_HUMANPNPH_HUMANBioGRID21800051 details
UCHL5_HUMANCYTA_HUMANBioGRID21800051 details
UCHL5_HUMANANXA1_HUMANBioGRID21800051 details
UCHL5_HUMANK2C73_HUMANBioGRID21800051 details
UCHL5_HUMANK2C78_HUMANBioGRID21800051 details
UCHL5_HUMANHSPB1_HUMANBioGRID21800051 details
UCHL5_HUMANANXA8_HUMANBioGRID21800051 details
UCHL5_HUMANAXA81_HUMANBioGRID21800051 details
UCHL5_HUMANKPYM_HUMANBioGRID21800051 details
UCHL5_HUMANDESP_HUMANBioGRID21800051 details
UCHL5_HUMANFILA_HUMANBioGRID21800051 details
UCHL5_HUMANGSTM3_HUMANBioGRID21800051 details
UCHL5_HUMANSPB3_HUMANBioGRID21800051 details
UCHL5_HUMANS10A7_HUMANBioGRID21800051 details
UCHL5_HUMAN1433Z_HUMANBioGRID21800051 details
UCHL5_HUMANK1C28_HUMANBioGRID21800051 details
UCHL5_HUMANK1C26_HUMANBioGRID21800051 details
UCHL5_HUMANK1C12_HUMANBioGRID21800051 details
UCHL5_HUMANK1C19_HUMANBioGRID21800051 details
UCHL5_HUMANSPB5_HUMANBioGRID21800051 details
UCHL5_HUMANEPIPL_HUMANBioGRID21800051 details
UCHL5_HUMANTBA4A_HUMANBioGRID21800051 details
UCHL5_HUMANPRDX1_HUMANBioGRID21800051 29377617 details
UCHL5_HUMANTGM3_HUMANBioGRID21800051 details
UCHL5_HUMANPKP1_HUMANBioGRID21800051 details
UCHL5_HUMANDSC3_HUMANBioGRID21800051 details
UCHL5_HUMANAN32B_HUMANBioGRID21800051 details
UCHL5_HUMANPRDX6_HUMANBioGRID21800051 details
UCHL5_HUMANCDSN_HUMANBioGRID21800051 details
UCHL5_HUMANS10AG_HUMANBioGRID21800051 details
UCHL5_HUMANEF2_HUMANBioGRID21800051 details
UCHL5_HUMANIDE_HUMANBioGRID21800051 details
UCHL5_HUMANHBA_HUMANBioGRID21800051 details
UCHL5_HUMANHBB_HUMANBioGRID21800051 details
UCHL5_HUMANSPB12_HUMANBioGRID21800051 details
UCHL5_HUMANDUS14_HUMANBioGRID21800051 details
UCHL5_HUMANANXA7_HUMANBioGRID21800051 details
UCHL5_HUMANCOF1_HUMANBioGRID21800051 details
UCHL5_HUMANRAB7A_HUMANBioGRID21800051 details
UCHL5_HUMANTPIS_HUMANBioGRID21800051 details
UCHL5_HUMANIF4A1_HUMANBioGRID21800051 details
UCHL5_HUMANCAP1_HUMANBioGRID21800051 details
UCHL5_HUMANNACA_HUMANBioGRID21800051 details
UCHL5_HUMANNACAM_HUMANBioGRID21800051 details
UCHL5_HUMANTHIOM_HUMANBioGRID21800051 details
UCHL5_HUMANCATD_HUMANBioGRID21800051 details
UCHL5_HUMANCAZA1_HUMANBioGRID21800051 details
UCHL5_HUMANLMNA_HUMANBioGRID21800051 details
UCHL5_HUMANINVO_HUMANBioGRID21800051 details
UCHL5_HUMANAN32E_HUMANBioGRID21800051 details
UCHL5_HUMANANXA4_HUMANBioGRID21800051 details
UCHL5_HUMANS10AE_HUMANBioGRID21800051 details
UCHL5_HUMANEF1G_HUMANBioGRID21800051 details
UCHL5_HUMANTHIO_HUMANBioGRID21800051 details
UCHL5_HUMANCALM1_HUMANBioGRID15840729 details
UCHL5_HUMANCALM2_HUMANBioGRID15840729 details
UCHL5_HUMANCALM3_HUMANBioGRID15840729 details
UCHL5_HUMANUCHL5_HUMANBioGRID18922472 21953935 24752541 25702872 28292943 details
UCHL5_HUMANRFFL_HUMANBioGRID22626734 details
UCHL5_HUMANPJA1_HUMANBioGRID22626734 details
UCHL5_HUMANTRI63_HUMANBioGRID22626734 details
UCHL5_HUMANTRI55_HUMANBioGRID22626734 details
UCHL5_HUMANTRI54_HUMANBioGRID22626734 details
UCHL5_HUMANUBP28_HUMANBioGRID22626734 details
UCHL5_HUMANA4_HUMANBioGRID21832049 details
UCHL5_HUMANTRI27_HUMANBioGRID23105109 details
UCHL5_HUMANHOIL1_HUMANBioGRID23105109 details
UCHL5_HUMANTRI46_HUMANBioGRID23105109 details
UCHL5_HUMANPA2GA_HUMANBioGRID22118674 details
UCHL5_HUMANM3K1_HUMANBioGRID25260751 details
UCHL5_HUMANE2F1_HUMANBioGRID26396186 details
UCHL5_HUMANE2F2_HUMANBioGRID26396186 details
UCHL5_HUMANE2F3_HUMANBioGRID26396186 details
UCHL5_HUMANTCF7_HUMANBioGRID28198400 details
UCHL5_HUMANOGT1_HUMANBioGRID32994395 details
UCHL5_HUMANEIF1B_HUMANIntAct17353931 details
UCHL5_HUMANPSMD2_HUMANBioGRID, IntAct, MINT, UniProt16990800 18922472 19490896 19615732 22863883 22939629 26186194 28514442 details
UCHL5_HUMANPSA6_HUMANBioGRID, IntAct, MINT, UniProt16990800 18922472 19490896 details
UCHL5_HUMANPSDE_HUMANBioGRID, IntAct, UniProt17323924 18922472 19490896 19615732 22863883 24743594 26186194 26496610 28514442 details
UCHL5_HUMANPSA2_HUMANBioGRID, IntAct, UniProt18922472 19193609 19490896 26344197 details
UCHL5_HUMANIN80E_HUMANBioGRID, IntAct, UniProt17721549 18922472 19615732 21303910 24981860 26186194 28514442 details
UCHL5_HUMANTFPT_HUMANBioGRID, IntAct, UniProt17721549 18922472 19615732 24981860 26186194 28514442 details
UCHL5_HUMANIN80D_HUMANBioGRID, IntAct, UniProt17721549 18922472 24981860 28514442 details
UCHL5_HUMANRUVB1_HUMANBioGRID, IntAct, UniProt17721549 18922472 28514442 details
UCHL5_HUMANINO80_HUMANBioGRID, IntAct, UniProt18922472 21303910 24981860 26186194 28514442 28598414 details
UCHL5_HUMANARP8_HUMANBioGRID, IntAct, UniProt17721549 18922472 24981860 26186194 28514442 details
UCHL5_HUMANARP5_HUMANBioGRID, IntAct, UniProt17721549 18922472 26186194 26496610 28514442 details
UCHL5_HUMANMCRS1_HUMANBioGRID, IntAct, UniProt17721549 18922472 24981860 26186194 28514442 details
UCHL5_HUMANTYY1_HUMANBioGRID, IntAct, MINT, UniProt17721549 18922472 24981860 26186194 27705803 28514442 details
UCHL5_HUMANRUVB2_HUMANBioGRID, IntAct, UniProt17643375 17721549 18922472 28514442 details
UCHL5_HUMANSEM1_HUMANBioGRID, MINT24811749 28396413 details
UCHL5_HUMANNOS2_HUMANBioGRID, DIP20634424 23438482 details
UCHL5_HUMANRD23A_HUMANBioGRID19013454 details
UCHL5_HUMANCBX7_HUMANBioGRID21282530 details
UCHL5_HUMANPRP19_HUMANBioGRID23220010 details
UCHL5_HUMANSEML_HUMANBioGRID24811749 28396413 details
UCHL5_HUMANCTNB1_HUMANBioGRID30726867 details
UCHL5_HUMANSQSTM_HUMANBioGRID32292717 details