Entity Details

Primary name FTCD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95954
EntryNameFTCD_HUMAN
FullNameFormimidoyltransferase-cyclodeaminase
TaxID9606
Evidenceevidence at protein level
Length541
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesFTCD

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005542 folic acid binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005814 centriole
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006548 histidine catabolic process
GO:0006760 folic acid-containing compound metabolic process
GO:0007010 cytoskeleton organization
GO:0008017 microtubule binding
GO:0019556 histidine catabolic process to glutamate and formamide
GO:0019557 histidine catabolic process to glutamate and formate
GO:0030409 glutamate formimidoyltransferase activity
GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity
GO:0030868 smooth endoplasmic reticulum membrane
GO:0035999 tetrahydrofolate interconversion
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR004227 Formiminotransferase catalytic domainDomainDomain
IPR007044 Cyclodeaminase/cyclohydrolaseDomainDomain
IPR012886 Formiminotransferase, N-terminal subdomainDomainDomain
IPR013802 Formiminotransferase, C-terminal subdomainDomainDomain
IPR022384 Formiminotransferase catalytic domain superfamilyFamilyHomologous superfamily
IPR036178 Formimidoyltransferase-cyclodeaminase-like superfamilyFamilyHomologous superfamily
IPR037064 Formiminotransferase, N-terminal subdomain superfamilyFamilyHomologous superfamily
IPR037070 Formiminotransferase, C-terminal subdomain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00142 Glutamic acidDrugbanksmall molecule
DB03256 (6R)-Folinic acidDrugbanksmall molecule