Entity Details

Primary name KAD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00568
EntryNameKAD1_HUMAN
FullNameAdenylate kinase isoenzyme 1
TaxID9606
Evidenceevidence at protein level
Length194
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesAK1

GO terms

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GOName
GO:0004017 adenylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006172 ADP biosynthetic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0046033 AMP metabolic process
GO:0046034 ATP metabolic process
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000850 Adenylate kinase/UMP-CMP kinaseFamilyFamily
IPR006267 Adenylate kinase, isozyme 1/5FamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR028582 Adenylate kinase isoenzyme 1FamilyFamily
IPR033690 Adenylate kinase, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
612631 OMIMHemolytic anemia due to adenylate kinase deficiency (HAAKD)A disease characterized by hemolytic anemia and undetectable erythrocyte adenylate kinase activity. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01717 Bis(Adenosine)-5'-PentaphosphateDrugbanksmall molecule
DB09299 Tenofovir alafenamideDrugbanksmall molecule
DB14126 TenofovirDrugbanksmall molecule

Interactions

7 interactions