Entity Details

Primary name KLKB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP03952
EntryNameKLKB1_HUMAN
FullNamePlasma kallikrein
TaxID9606
Evidenceevidence at protein level
Length638
SequenceStatuscomplete
DateCreated1986-10-23
DateModified2021-06-02

Ontological Relatives

GenesKLKB1

GO terms

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GOName
GO:0002542 Factor XII activation
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0007597 blood coagulation, intrinsic pathway
GO:0022617 extracellular matrix disassembly
GO:0031638 zymogen activation
GO:0031639 plasminogen activation
GO:0042730 fibrinolysis
GO:0051919 positive regulation of fibrinolysis
GO:0070062 extracellular exosome
GO:2000267 negative regulation of blood coagulation, intrinsic pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000177 Apple domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR003609 PAN/Apple domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB05311 EcallantideDrugbankbiotech
DB06404 Human C1-esterase inhibitorDrugbankbiotech
DB09228 Conestat alfaDrugbankbiotech
DB12831 GabexateDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule
DB14597 LanadelumabDrugbankbiotech
DB15982 BerotralstatDrugbanksmall molecule