Entity Details

Primary name HEP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05546
EntryNameHEP2_HUMAN
FullNameHeparin cofactor 2
TaxID9606
Evidenceevidence at protein level
Length499
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesSERPIND1

GO terms

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GOName
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0006935 chemotaxis
GO:0007596 blood coagulation
GO:0008201 heparin binding
GO:0010951 negative regulation of endopeptidase activity
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR033831 Heparin cofactor II, serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00407 ArdeparinDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB06271 SulodexideDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB09258 BemiparinDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule