Entity Details

Primary name KAD4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27144
EntryNameKAD4_HUMAN
FullNameAdenylate kinase 4, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length223
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesAK4

GO terms

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GOName
GO:0001889 liver development
GO:0002082 regulation of oxidative phosphorylation
GO:0004017 adenylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006172 ADP biosynthetic process
GO:0007420 brain development
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0042493 response to drug
GO:0046033 AMP metabolic process
GO:0046034 ATP metabolic process
GO:0046039 GTP metabolic process
GO:0046899 nucleoside triphosphate adenylate kinase activity
GO:0071456 cellular response to hypoxia
GO:2001169 regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR000850 Adenylate kinase/UMP-CMP kinaseFamilyFamily
IPR006259 Adenylate kinase subfamilyFamilyFamily
IPR007862 Adenylate kinase, active site lid domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR028585 Adenylate kinase 4, mitochondrialFamilyFamily
IPR028586 Adenylate kinase 3/4, mitochondrialFamilyFamily
IPR033690 Adenylate kinase, conserved siteSiteConserved site
IPR036193 Adenylate kinase, active site lid domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00300 Tenofovir disoproxilDrugbanksmall molecule
DB00718 Adefovir dipivoxilDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
KAD4_HUMANEPHA8_HUMANBioGRID, IntAct21988832 details
KAD4_HUMANCEP19_HUMANBioGRID, IntAct21988832 details
KAD4_HUMANKEAP1_HUMANBioGRID, MINT21900206 details
KAD4_HUMANA4_HUMANBioGRID21832049 details