Entity Details

Primary name TPOR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40238
EntryNameTPOR_HUMAN
FullNameThrombopoietin receptor
TaxID9606
Evidenceevidence at protein level
Length635
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesMPL

GO terms

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GOName
GO:0001780 neutrophil homeostasis
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0035702 monocyte homeostasis
GO:0038164 thrombopoietin receptor activity
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0050671 positive regulation of lymphocyte proliferation
GO:0070527 platelet aggregation
GO:0071456 cellular response to hypoxia
GO:1905221 positive regulation of platelet formation
GO:1990959 eosinophil homeostasis
GO:1990960 basophil homeostasis

Subcellular Location

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Subcellular Location
Cell membrane
Cell surface
Golgi apparatus

Domains

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DomainNameCategoryType
IPR003528 Long hematopoietin receptor, single chain, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015152 Growth hormone/erythropoietin receptor, ligand bindingDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05332 RomiplostimDrugbankbiotech
DB05930 SB-559448Drugbanksmall molecule
DB06210 EltrombopagDrugbanksmall molecule
DB06534 ThrombopoietinDrugbankbiotech
DB11995 AvatrombopagDrugbanksmall molecule
DB13125 LusutrombopagDrugbanksmall molecule