Entity Details

Primary name TEC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42680
EntryNameTEC_HUMAN
FullNameTyrosine-protein kinase Tec
TaxID9606
Evidenceevidence at protein level
Length631
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesTEC

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007229 integrin-mediated signaling pathway
GO:0010543 regulation of platelet activation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042246 tissue regeneration
GO:0046872 metal ion binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001562 Zinc finger, Btk motifSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035572 Tyrosine-protein kinase Tec, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
TEC_HUMANERBB2_HUMANBioGRID, MINT16273093 details
TEC_HUMANPTPRC_HUMANIntAct19167335 details
TEC_HUMANPTPRK_HUMANIntAct19167335 details
TEC_HUMANPTPRG_HUMANIntAct19167335 details
TEC_HUMANPTPRB_HUMANIntAct19167335 details
TEC_HUMANPTPRJ_HUMANIntAct19167335 details
TEC_HUMANPTPRO_HUMANIntAct19167335 details
TEC_HUMANPTN12_HUMANIntAct19167335 details
TEC_HUMANMED28_HUMANBioGRID, MINT16964398 details
TEC_HUMANASAP1_HUMANMINT16636290 details
TEC_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
TEC_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
TEC_HUMANKIT_HUMANBioGRID, HPRD, IntAct11071635 24728074 7526158 details
TEC_HUMANMET_HUMANBioGRID, IntAct24728074 details
TEC_HUMANWASP_HUMANbhf-ucl, BioGRID, HPRD8892607 details
TEC_HUMANADAM8_HUMANUniProt25825872 details
TEC_HUMANADAM9_HUMANUniProt25825872 details
TEC_HUMANADA15_HUMANUniProt25825872 details
TEC_HUMANADA19_HUMANUniProt25825872 details
TEC_HUMANPRLR_HUMANBioGRID, HPRD11328862 details
TEC_HUMANJAK2_HUMANBioGRID, HPRD9178903 9473212 details
TEC_HUMANP85B_HUMANBioGRID9178903 details
TEC_HUMANDOK1_HUMANBioGRID, HPRD10823839 11071635 11825908 details
TEC_HUMANSOCS1_HUMANBioGRID, HPRD29991678 9341160 details
TEC_HUMANARHGC_HUMANBioGRID12515866 details
TEC_HUMANNEMO_HUMANBioGRID20098747 details
TEC_HUMANFBX7_HUMANBioGRID27503909 details
TEC_HUMANLRRK1_HUMANBioGRID29513927 details
TEC_HUMANEGFR_HUMANBioGRID22973453 details
TEC_HUMANERBB3_HUMANBioGRID22973453 details
TEC_HUMANERBB4_HUMANBioGRID22973453 details
TEC_HUMANTMG4_HUMANBioGRID23873930 details
TEC_HUMANP55G_HUMANHPRD9178903 details
TEC_HUMANPLK4_HUMANHPRD11489907 details
TEC_HUMANVAV_HUMANBioGRID, HPRD11328862 7651724 details
TEC_HUMANJAK1_HUMANBioGRID, HPRD9178903 details
TEC_HUMANLYN_HUMANBioGRID, HPRD11071635 8621063 9446655 details
TEC_HUMANGNA12_HUMANBioGRID, HPRD12515866 details
TEC_HUMANSHC1_HUMANBioGRID, HPRD11825908 19380743 details
TEC_HUMANBMX_HUMANHPRD12573241 details
TEC_HUMANBTK_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
TEC_HUMANTEC_HUMANHPRD12573241 details
TEC_HUMANPTN21_HUMANHPRD11013262 details
TEC_HUMANPTN18_HUMANHPRD14679216 15588985 details
TEC_HUMANSTAP1_HUMANHPRD10518561 11716489 details
TEC_HUMANP85A_HUMANHPRD9178903 details
TEC_HUMANPLCG1_HUMANHPRD10823839 details
TEC_HUMANPLCG2_HUMANHPRD15184383 details
TEC_HUMANPI51A_HUMANHPRD14614854 details
TEC_HUMANPI42A_HUMANHPRD14614854 details
TEC_HUMANP53_HUMANHPRD15355990 details