Entity Details

Primary name DYN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05193
EntryNameDYN1_HUMAN
FullNameDynamin-1
TaxID9606
Evidenceevidence at protein level
Length864
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesDNM1

GO terms

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GOName
GO:0000266 mitochondrial fission
GO:0003374 dynamin family protein polymerization involved in mitochondrial fission
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007032 endosome organization
GO:0008017 microtubule binding
GO:0014069 postsynaptic density
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0019901 protein kinase binding
GO:0030424 axon
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0031966 mitochondrial membrane
GO:0042802 identical protein binding
GO:0044327 dendritic spine head
GO:0048013 ephrin receptor signaling pathway
GO:0050803 regulation of synapse structure or activity
GO:0061025 membrane fusion
GO:0070062 extracellular exosome
GO:0098793 presynapse
GO:0098844 postsynaptic endocytic zone membrane
GO:0098884 postsynaptic neurotransmitter receptor internalization

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000375 Dynamin stalk domainDomainDomain
IPR001401 Dynamin, GTPase domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR003130 Dynamin GTPase effectorDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019762 Dynamin, GTPase region, conserved siteSiteConserved site
IPR020850 GTPase effector domainDomainDomain
IPR022812 DynaminFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR027741 Dynamin-1FamilyFamily
IPR030381 Dynamin-type guanine nucleotide-binding (G) domainDomainDomain

Diseases

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Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
DYN1_HUMANAMPH_HUMANBioGRID, HPRD, MINT10542231 10899172 11877424 15834155 17244534 29357276 9148966 9280305 9341169 9348539 9694653 details
DYN1_HUMANSH3G1_HUMANBioGRID, HPRD, MINT10542231 10764144 9238017 details
DYN1_HUMANSNX9_HUMANBioGRID, HPRD, IntAct, MINT, UniProt15703209 16137687 18353773 28514442 details
DYN1_HUMANSH3G2_HUMANBioGRID, HPRD, MINT11877424 15834155 9238017 9341169 details
DYN1_HUMANITSN1_HUMANBioGRID, HPRD, MINT10373452 15834155 18539136 details
DYN1_HUMANSRC_HUMANBioGRID, HPRD, MINT12011079 15834155 19380485 9880482 details
DYN1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10206341 11877424 15834155 17244534 17474147 19380743 21706016 28514442 31980649 7597091 8119878 9009162 9478994 details
DYN1_HUMANCE126_HUMANBioGRID, HPRD, IntAct16169070 details
DYN1_HUMANMED31_HUMANBioGRID, HPRD, IntAct16169070 details
DYN1_HUMANASB13_HUMANBioGRID, HPRD, IntAct16169070 details
DYN1_HUMANPIN4_HUMANBioGRID, HPRD, IntAct16169070 details
DYN1_HUMANTIM50_HUMANHPRD, IntAct16169070 details
DYN1_HUMANNCK1_HUMANBioGRID, HPRD, IntAct10206341 11557983 details
DYN1_HUMANPACN1_HUMANBioGRID, HPRD, UniProt11082044 15252009 9950691 details
DYN1_HUMANABL1_HUMANIntAct17474147 details
DYN1_HUMANBIN1_HUMANBioGRID, HPRD, IntAct16275660 9195986 9280305 details
DYN1_HUMANU2D2L_HUMANIntAct19549727 details
DYN1_HUMANDYN1_HUMANBioGRID, DIP, HPRD, IntAct, MINT15123615 20428113 20700106 21927000 21962517 26302298 30069048 7634088 7954789 details
DYN1_HUMANDYN2_HUMANBioGRID, MINT21900206 details
DYN1_HUMANHD_HUMANIntAct17500595 details
DYN1_HUMANLRRK2_HUMANBioGRID, IntAct24282027 details
DYN1_HUMANSPTCS_HUMANIntAct29949766 details
DYN1_HUMANDNMBP_HUMANBioGRID, HPRD14506234 details
DYN1_HUMANPACN3_HUMANBioGRID, HPRD11082044 details
DYN1_HUMANPACN2_HUMANBioGRID11082044 details
DYN1_HUMANM3K10_HUMANBioGRID9742220 details
DYN1_HUMANEPN4_HUMANBioGRID12429846 details
DYN1_HUMANDYR1A_HUMANBioGRID11877424 19722700 details
DYN1_HUMANCDK5_HUMANBioGRID, HPRD12855954 15834155 details
DYN1_HUMANSUMO1_HUMANBioGRID15123615 details
DYN1_HUMANPIAS1_HUMANBioGRID, HPRD15123615 details
DYN1_HUMANUBC9_HUMANBioGRID15123615 details
DYN1_HUMANNCK2_HUMANBioGRID, HPRD11557983 details
DYN1_HUMANFNBP1_HUMANBioGRID, HPRD, UniProt15252009 details
DYN1_HUMANMYO1E_HUMANMINT17257598 details
DYN1_HUMANNOSTN_HUMANMINT16234328 details
DYN1_HUMANUBS3A_HUMANBioGRID, MINT17382318 31659016 details
DYN1_HUMANSNX33_HUMANUniProt18353773 details
DYN1_HUMANNOS3_HUMANDIP16432212 details
DYN1_HUMANNDKA_HUMANDIP20713695 details
DYN1_HUMANFER_HUMANBioGRID9722593 details
DYN1_HUMANCABIN_HUMANBioGRID, HPRD10931822 details
DYN1_HUMANADAM2_HUMANBioGRID16049941 details
DYN1_HUMANSH3K1_HUMANBioGRID19531213 details
DYN1_HUMANFAK2_HUMANBioGRID19380485 details
DYN1_HUMANSH3B4_HUMANBioGRID16325581 details
DYN1_HUMANFAK1_HUMANBioGRID7597091 details
DYN1_HUMANDRD2_HUMANBioGRID14709338 details
DYN1_HUMANPROF2_HUMANHPRD9463375 details
DYN1_HUMANPRIO_HUMANHPRD15146195 details
DYN1_HUMANKPCA_HUMANHPRD10766777 details
DYN1_HUMANSNP25_HUMANHPRD10373452 details
DYN1_HUMANNMDE4_HUMANHPRD10862698 details
DYN1_HUMANSH3G3_HUMANHPRD9238017 details
DYN1_HUMANCLIC3_HUMANHPRD11563969 details
DYN1_HUMANCLIC4_HUMANHPRD11563969 details
DYN1_HUMANAP2A2_HUMANHPRD10430869 details
DYN1_HUMANEPS15_HUMANHPRD11483962 details
DYN1_HUMANPHOCN_HUMANHPRD11872741 details
DYN1_HUMANNMDZ1_HUMANHPRD10862698 details
DYN1_HUMANP85A_HUMANHPRD11341978 details
DYN1_HUMANPLCG1_HUMANHPRD15252117 details
DYN1_HUMANCAV1_HUMANHPRD11956154 details
DYN1_HUMANRACK1_HUMANHPRD12359736 details
DYN1_HUMANNDKB_HUMANHPRD11872741 details
DYN1_HUMANSRC8_HUMANHPRD12419186 details