Entity Details

Primary name PLCB4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15147
EntryNamePLCB4_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
TaxID9606
Evidenceevidence at protein level
Length1175
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesPLCB4

GO terms

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GOName
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0005509 calcium ion binding
GO:0005634 nucleus
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0007186 G protein-coupled receptor signaling pathway
GO:0014069 postsynaptic density
GO:0016042 lipid catabolic process
GO:0030425 dendrite
GO:0043647 inositol phosphate metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050804 modulation of chemical synaptic transmission
GO:0098688 parallel fiber to Purkinje cell synapse
GO:0098978 glutamatergic synapse

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR009535 Phospholipase C-beta, conserved siteSiteConserved site
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domainDomainDomain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase betaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR037862 PLC-beta, PH domainDomainDomain
IPR042531 Phospholipase C-beta, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions