Entity Details

Primary name AL1L2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ3SY69
EntryNameAL1L2_HUMAN
FullNameMitochondrial 10-formyltetrahydrofolate dehydrogenase
TaxID9606
Evidenceevidence at protein level
Length923
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesALDH1L2

GO terms

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GOName
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006730 one-carbon metabolic process
GO:0009058 biosynthetic process
GO:0009258 10-formyltetrahydrofolate catabolic process
GO:0016155 formyltetrahydrofolate dehydrogenase activity
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
GO:0046655 folic acid metabolic process
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR001555 Phosphoribosylglycinamide formyltransferase, active siteSiteActive site
IPR002376 Formyl transferase, N-terminalDomainDomain
IPR005793 Formyl transferase, C-terminalDomainDomain
IPR006162 Phosphopantetheine attachment sitePTMPTM
IPR009081 Phosphopantetheine binding ACP domainDomainDomain
IPR011034 Formyl transferase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR011407 10-formyltetrahydrofolate dehydrogenaseFamilyFamily
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016160 Aldehyde dehydrogenase, cysteine active siteSiteConserved site
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily
IPR029510 Aldehyde dehydrogenase, glutamic acid active siteSiteConserved site
IPR036477 Formyl transferase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036736 ACP-like superfamilyFamilyHomologous superfamily
IPR037022 Formyl transferase, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AL1L2_HUMANHD_HUMANIntAct32814053 details