Entity Details

Primary name STEA3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ658P3
EntryNameSTEA3_HUMAN
FullNameMetalloreductase STEAP3
TaxID9606
Evidenceevidence at protein level
Length488
SequenceStatuscomplete
DateCreated2007-05-01
DateModified2021-06-02

Ontological Relatives

GenesSTEAP3

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0008823 cupric reductase activity
GO:0009306 protein secretion
GO:0010008 endosome membrane
GO:0015677 copper ion import
GO:0016021 integral component of membrane
GO:0033572 transferrin transport
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
GO:0055072 iron ion homeostasis

Subcellular Location

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Subcellular Location
Endosome membrane

Domains

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DomainNameCategoryType
IPR013130 Ferric reductase transmembrane component-like domainDomainDomain
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminalDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615234 OMIMAnemia, hypochromic microcytic, with iron overload 2 (AHMIO2)A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. The disease is caused by variants affecting the gene represented in this entry.