Entity Details

Primary name PCSK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6UW60
EntryNamePCSK4_HUMAN
FullNameProprotein convertase subtilisin/kexin type 4
TaxID9606
Evidenceevidence at protein level
Length755
SequenceStatuscomplete
DateCreated2006-07-25
DateModified2021-04-07

Ontological Relatives

GenesPCSK4

GO terms

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GOName
GO:0001669 acrosomal vesicle
GO:0002080 acrosomal membrane
GO:0004252 serine-type endopeptidase activity
GO:0005802 trans-Golgi network
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0009566 fertilization
GO:0016020 membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0022414 reproductive process
GO:0030173 integral component of Golgi membrane
GO:0048240 sperm capacitation

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Membrane

Domains

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DomainNameCategoryType
IPR000209 Peptidase S8/S53 domainDomainDomain
IPR002884 P domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR015500 Peptidase S8, subtilisin-relatedFamilyFamily
IPR022398 Peptidase S8, subtilisin, His-active siteSiteActive site
IPR023827 Peptidase S8, subtilisin, Asp-active siteSiteActive site
IPR023828 Peptidase S8, subtilisin, Ser-active siteSiteActive site
IPR032815 Peptidase S8, pro-domainDomainDomain
IPR034182 Kexin/furin catalytic domainDomainDomain
IPR036852 Peptidase S8/S53 domain superfamilyFamilyHomologous superfamily
IPR038466 Peptidase S8, pro-domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
PCSK4_HUMANASPH_HUMANBioGRID, IntAct32296183 details
PCSK4_HUMANHD_HUMANIntAct32814053 details
PCSK4_HUMANIGF2_HUMANBioGRID, HPRD16040806 details