Entity Details

Primary name MAPK5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IW41
EntryNameMAPK5_HUMAN
FullNameMAP kinase-activated protein kinase 5
TaxID9606
Evidenceevidence at protein level
Length473
SequenceStatuscomplete
DateCreated2004-09-13
DateModified2021-06-02

Ontological Relatives

GenesMAPKAPK5

GO terms

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GOName
GO:0002039 p53 binding
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006417 regulation of translation
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0032007 negative regulation of TOR signaling
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
GO:0051019 mitogen-activated protein kinase binding
GO:0051973 positive regulation of telomerase activity
GO:0090400 stress-induced premature senescence
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904355 positive regulation of telomere capping

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
MAPK5_HUMANP53_HUMANBioGRID, HPRD, IntAct17254968 details
MAPK5_HUMANMK14_HUMANBioGRID, HPRD, IntAct20936779 9628874 details
MAPK5_HUMANMK06_HUMANBioGRID, HPRD, IntAct, MINT18720373 20936779 21900206 23602568 25416956 26972000 28514442 29426014 32296183 details
MAPK5_HUMANLSR_HUMANBioGRID, IntAct21988832 details
MAPK5_HUMANBOREA_HUMANBioGRID, IntAct21988832 details
MAPK5_HUMANZN576_HUMANBioGRID, IntAct21988832 details
MAPK5_HUMANHSPB1_HUMANBioGRID, HPRD, Molecular Connections10978313 19166925 21575178 9628874 details
MAPK5_HUMANTAB1_HUMANBioGRID, MINT21900206 details
MAPK5_HUMANRL13_HUMANBioGRID, MINT21900206 details
MAPK5_HUMANZN282_HUMANBioGRID, MINT21900206 details
MAPK5_HUMANMK04_HUMANBioGRID, HPRD, IntAct18720373 21675959 23602568 details
MAPK5_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
MAPK5_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
MAPK5_HUMANRAGE_HUMANUniProt26758977 details
MAPK5_HUMANHMGB1_HUMANUniProt31694235 details
MAPK5_HUMANHSPB2_HUMANBioGRID9628874 details
MAPK5_HUMANMAPK2_HUMANBioGRID21675959 details
MAPK5_HUMANMAPK5_HUMANBioGRID19166925 details
MAPK5_HUMANPARK7_HUMANBioGRID25383140 details
MAPK5_HUMANMK01_HUMANBioGRID, HPRD, IntAct25241761 9628874 details
MAPK5_HUMANMK09_HUMANBioGRID, HPRD, IntAct25241761 9628874 details
MAPK5_HUMAN4EBP1_HUMANBioGRID, HPRD, IntAct25241761 9628874 details
MAPK5_HUMANYAP1_HUMANBioGRID31578200 details
MAPK5_HUMANKC1E_HUMANBioGRID31578200 details
MAPK5_HUMANJUN_HUMANHPRD9628874 details
MAPK5_HUMANMK12_HUMANHPRD9628874 details
MAPK5_HUMANMK11_HUMANHPRD9628874 details
MAPK5_HUMANEF2K_HUMANHPRD12171600 details
MAPK5_HUMANPA24A_HUMANHPRD10978317 8636128 9468497 details
MAPK5_HUMANMK13_HUMANHPRD9628874 details
MAPK5_HUMANATF2_HUMANHPRD9628874 details
MAPK5_HUMANIF4E_HUMANHPRD9628874 details
MAPK5_HUMANGYS1_HUMANHPRD9628874 details
MAPK5_HUMANMBP_HUMANHPRD9628874 details
MAPK5_HUMANMYH11_HUMANHPRD9628874 details