Entity Details

Primary name NLGN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N2Q7
EntryNameNLGN1_HUMAN
FullNameNeuroligin-1
TaxID9606
Evidenceevidence at protein level
Length863
SequenceStatuscomplete
DateCreated2003-05-23
DateModified2021-06-02

Ontological Relatives

GenesNLGN1

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006605 protein targeting
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007158 neuron cell-cell adhesion
GO:0007268 chemical synaptic transmission
GO:0007399 nervous system development
GO:0007416 synapse assembly
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0014069 postsynaptic density
GO:0016080 synaptic vesicle targeting
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0017146 NMDA selective glutamate receptor complex
GO:0023041 neuronal signal transduction
GO:0030165 PDZ domain binding
GO:0030425 dendrite
GO:0031175 neuron projection development
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032433 filopodium tip
GO:0035418 protein localization to synapse
GO:0038023 signaling receptor activity
GO:0042043 neurexin family protein binding
GO:0042802 identical protein binding
GO:0043083 synaptic cleft
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043235 receptor complex
GO:0044877 protein-containing complex binding
GO:0045184 establishment of protein localization
GO:0045202 synapse
GO:0045664 regulation of neuron differentiation
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
GO:0048511 rhythmic process
GO:0048789 cytoskeletal matrix organization at active zone
GO:0050804 modulation of chemical synaptic transmission
GO:0050839 cell adhesion molecule binding
GO:0051491 positive regulation of filopodium assembly
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060076 excitatory synapse
GO:0060291 long-term synaptic potentiation
GO:0060999 positive regulation of dendritic spine development
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0071277 cellular response to calcium ion
GO:0072553 terminal button organization
GO:0089717 spanning component of membrane
GO:0097091 synaptic vesicle clustering
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097110 scaffold protein binding
GO:0097113 AMPA glutamate receptor clustering
GO:0097114 NMDA glutamate receptor clustering
GO:0097115 neurexin clustering involved in presynaptic membrane assembly
GO:0097119 postsynaptic density protein 95 clustering
GO:0097120 receptor localization to synapse
GO:0098698 postsynaptic specialization assembly
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex
GO:0098985 asymmetric, glutamatergic, excitatory synapse
GO:0099054 presynapse assembly
GO:0099055 integral component of postsynaptic membrane
GO:0099060 integral component of postsynaptic specialization membrane
GO:0099560 synaptic membrane adhesion
GO:0140058 neuron projection arborization
GO:1900029 positive regulation of ruffle assembly
GO:1900244 positive regulation of synaptic vesicle endocytosis
GO:1902474 positive regulation of protein localization to synapse
GO:1902533 positive regulation of intracellular signal transduction
GO:1904861 excitatory synapse assembly
GO:1905520 positive regulation of presynaptic active zone assembly
GO:2000302 positive regulation of synaptic vesicle exocytosis
GO:2000310 regulation of NMDA receptor activity
GO:2000311 regulation of AMPA receptor activity
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000809 positive regulation of synaptic vesicle clustering

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000460 NeuroliginFamilyFamily
IPR002018 Carboxylesterase, type BDomainDomain
IPR019819 Carboxylesterase type B, conserved siteSiteConserved site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR030022 Neuroligin-1FamilyFamily

Diseases

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