Entity Details

Primary name TR10A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00220
EntryNameTR10A_HUMAN
FullNameTumor necrosis factor receptor superfamily member 10A
TaxID9606
Evidenceevidence at protein level
Length468
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesTNFRSF10A

GO terms

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GOName
GO:0002020 protease binding
GO:0005035 death receptor activity
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008134 transcription factor binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0045121 membrane raft
GO:0045569 TRAIL binding
GO:0050900 leukocyte migration
GO:0071260 cellular response to mechanical stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane raft

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020465 Tumour necrosis factor receptor 10FamilyFamily
IPR034024 Tumor necrosis factor receptor 10, N-terminalDomainDomain
IPR034029 Tumour necrosis factor receptor 10A/B, death domainDomainDomain

Diseases

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Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
TR10A_HUMANTNF10_HUMANBioGRID, HPRD, IntAct, MINT10549288 10894160 19427028 20103630 9082980 9325248 details
TR10A_HUMANARAP1_HUMANIntAct18165900 details
TR10A_HUMANCASP8_HUMANBioGRID, HPRD, IntAct12218097 15280356 15388581 17047155 19343040 19427028 20103630 21785459 23142077 27321185 28514442 29274253 29795330 9325248 details
TR10A_HUMANBCL10_HUMANBioGRID, HPRD10400625 details
TR10A_HUMANRT29_HUMANBioGRID, HPRD11376335 details
TR10A_HUMANCASPA_HUMANBioGRID, IntAct19427028 9325248 details
TR10A_HUMANCFLAR_HUMANBioGRID, IntAct19343040 19427028 23142077 27321185 9325248 details
TR10A_HUMANTR10B_HUMANBioGRID, HPRD, IntAct15388581 16319225 19427028 28514442 29795330 9430228 details
TR10A_HUMANFADD_HUMANBioGRID, HPRD, IntAct15280356 15388581 19427028 21785459 23142077 27321185 28514442 29274253 29795330 9430227 details
TR10A_HUMANCUL3_HUMANBioGRID, IntAct19427028 23142077 details
TR10A_HUMANPARK7_HUMANIntAct21785459 details
TR10A_HUMANLG3BP_HUMANBioGRID, IntAct30833792 details
TR10A_HUMANTRADD_HUMANBioGRID, HPRD9430227 details
TR10A_HUMANCBL_HUMANBioGRID19932172 details
TR10A_HUMANTRAF2_HUMANBioGRID23142077 details
TR10A_HUMANMARH1_HUMANBioGRID23300075 details
TR10A_HUMANMARH8_HUMANBioGRID23300075 details
TR10A_HUMANTNAP3_HUMANBioGRID29274253 details
TR10A_HUMANRIPK1_HUMANHPRD9430227 details
TR10A_HUMANMOAP1_HUMANHPRD15949439 details
TR10A_HUMANRASF1_HUMANHPRD15949439 details
TR10A_HUMANCO2A1_HUMANHPRD9811967 details
TR10A_HUMANCD4_HUMANHPRD7650480 details
TR10A_HUMANBTK_HUMANHPRD15007095 details
TR10A_HUMANMADD_HUMANHPRD15208670 details
TR10A_HUMANTR10A_HUMANHPRD16319225 details
TR10A_HUMANTR10D_HUMANHPRD16319225 details