Entity Details

Primary name DOCK8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NF50
EntryNameDOCK8_HUMAN
FullNameDedicator of cytokinesis protein 8
TaxID9606
Evidenceevidence at protein level
Length2099
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesDOCK8

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0007264 small GTPase mediated signal transduction
GO:0016020 membrane
GO:0031256 leading edge membrane
GO:0031258 lamellipodium membrane
GO:0036336 dendritic cell migration
GO:0043547 positive regulation of GTPase activity
GO:0061485 memory T cell proliferation
GO:0070233 negative regulation of T cell apoptotic process
GO:1903905 positive regulation of establishment of T cell polarity
GO:1990869 cellular response to chemokine
GO:2000406 positive regulation of T cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR021816 Dedicator of cytokinesis C/D, N-terminalDomainDomain
IPR026791 Dedicator of cytokinesisFamilyFamily
IPR027007 C2 DOCK-type domainDomainDomain
IPR027357 DOCKER domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR037808 Dedicator of cytokinesis C, C2 domainDomainDomain
IPR043161 Dedicator of cytokinesis, C-terminal, lobe AFamilyHomologous superfamily
IPR043162 Dedicator of cytokinesis, C-terminal, lobe CFamilyHomologous superfamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
DOCK8_HUMANSMAD2_HUMANBioGRID, MINT15231748 details
DOCK8_HUMANLRCH3_HUMANBioGRID, IntAct24255178 25416956 28514442 32203420 details
DOCK8_HUMANLRCH1_HUMANBioGRID, IntAct24255178 25416956 28514442 31515488 32203420 details
DOCK8_HUMANCHM2A_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANHBAZ_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANBYST_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANRTP5_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANF161A_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANF124A_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANMEOX2_HUMANBioGRID, IntAct25416956 32296183 details
DOCK8_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANMED30_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANEXOS5_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANFANCL_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANFXL12_HUMANBioGRID, IntAct25416956 29892012 details
DOCK8_HUMANZN581_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANCHSP1_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANDOCK8_HUMANBioGRID, IntAct25416956 details
DOCK8_HUMANPIMRE_HUMANBioGRID, IntAct26871637 details
DOCK8_HUMANCOG6_HUMANBioGRID, IntAct32296183 details
DOCK8_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
DOCK8_HUMANCDC42_HUMANBioGRID, HPRD15304341 details
DOCK8_HUMANRAC1_HUMANBioGRID, HPRD15304341 details
DOCK8_HUMANDGCR6_HUMANBioGRID24722188 details
DOCK8_HUMANRM38_HUMANBioGRID25416956 details
DOCK8_HUMANMTG1_HUMANBioGRID25416956 details
DOCK8_HUMANZC3H1_HUMANBioGRID25416956 details
DOCK8_HUMANRHOQ_HUMANHPRD15304341 details
DOCK8_HUMANRHOJ_HUMANHPRD15304341 details
DOCK8_HUMANMYD88_HUMANInnateDB22581261 details
DOCK8_HUMANSRC_HUMANInnateDB22581261 details
DOCK8_HUMANLYN_HUMANInnateDB22581261 details
DOCK8_HUMANLRCH2_HUMANBioGRID, IntAct24255178 28514442 32203420 details
DOCK8_HUMANLRCH4_HUMANBioGRID, IntAct28514442 32203420 details