Entity Details
| Primary name |
USP9Y_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | O00507 |
| EntryName | USP9Y_HUMAN |
| FullName | Probable ubiquitin carboxyl-terminal hydrolase FAF-Y |
| TaxID | 9606 |
| Evidence | evidence at transcript level |
| Length | 2555 |
| SequenceStatus | complete |
| DateCreated | 1997-11-01 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Cytoplasm |
Domains
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| Domain | Name | Category | Type |
| IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Domain | Domain |
| IPR016024 | Armadillo-type fold | Family | Homologous superfamily |
| IPR018200 | Ubiquitin specific protease, conserved site | Site | Conserved site |
| IPR021905 | Domain of unknown function DUF3517 | Domain | Domain |
| IPR028889 | Ubiquitin specific protease domain | Domain | Domain |
| IPR038765 | Papain-like cysteine peptidase superfamily | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 415000 | OMIM | Spermatogenic failure Y-linked 2 (SPGFY2) | A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. The disease may be caused by variants affecting the gene represented in this entry. The role of USP9Y in spermatogenesis failure is uncertain (PubMed:19246359). A 4-bp deletion in a splice-donor site, causing exon skipping and protein truncation has been observed in non-obstructive azoospermia (PubMed:10581029). However, complete USP9Y deletion has been detected in individuals with no spermatogenic defects (PubMed:19246359). |
Interactions
3 interactions