Entity Details

Primary name P3C2B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00750
EntryNameP3C2B_HUMAN
FullNamePhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
TaxID9606
Evidenceevidence at protein level
Length1634
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesPIK3C2B

GO terms

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GOName
GO:0001727 lipid kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0006661 phosphatidylinositol biosynthetic process
GO:0009267 cellular response to starvation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016477 cell migration
GO:0030139 endocytic vesicle
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091 phosphatidylinositol binding
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043491 protein kinase B signaling
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0052742 phosphatidylinositol kinase activity
GO:1905037 autophagosome organization

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum
Microsome
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainDomainDomain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domainDomainDomain
IPR001683 Phox homologyDomainDomain
IPR002420 C2 phosphatidylinositol 3-kinase-type domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015433 Phosphatidylinositol kinaseFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036871 PX domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR042134 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, PX domainDomainDomain
IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule